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MetabolomicsComparative metabolomic responses to gibberellic acid and 6-benzylaminopurine in Cunila menthoides Benth. (Lamiaceae): a contribution to understand the metabolic pathways
Little is known about the effects of 6-benzylaminopurine (BA) and gibberellic acid (GA3) on the synthesis of secondary metabolites in species of Lamiaceae. In this study, for the first time, the profile of secondary metabolites in plantlets of Cunila menthoides was characterized, using UPLC-ESI-Qq-o...
2018-05-24 | MTBLS581 | MetaboLights
ProteomicsDifferent Binding Motifs of the Celiac Disease Associated HLA Molecules DQ2.5, DQ2.2 and DQ7.5 Revealed by Relative Quantitative Proteomics of Endogenous Peptide Repertoires
In this study relative quantitative analysis of endogenous peptides by mass spectrometry combined with neural network analysis have been used to address why the alpha- or beta-chain sharing human leukocyte antigen (HLA)-DQ molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for celiac disease. ...
ORGANISM(S): Homo sapiens (Human) 
2014-12-04 | PXD001205 | Pride
Hla Celiac disease Affinity precipitation Lc-ms/ms 
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080779 | MassIVE
ProteomicsDifferent Binding Motifs of the Celiac Disease Associated HLA Molecules DQ2.5, DQ2.2 and DQ7.5 Revealed by Relative Quantitative Proteomics of Endogenous Peptide Repertoires
In this study relative quantitative analysis of endogenous peptides by mass spectrometry combined with neural network analysis have been used to address why the alpha- or beta-chain sharing human leukocyte antigen (HLA)-DQ molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for celiac disease. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080859 | MassIVE
ProteomicsProteomic and metabolomic analysis of Azospirillum brasilense ntrC mutant under high and low nitrogen conditions
Azospirillum brasilense is a free-living diazothophic bacterium that associates with important grasses and cereals, promoting plant growth and increasing crop productivity. The nitrogen metabolism in this organism is tightly regulated by the availability of nitrogen and by the Ntr regulatory system....
ORGANISM(S): Azospirillum brasilense FP2 
2019-10-14 | PXD014120 | Pride
Azospirillum brasilense. ntrc. nitrogen metabolism. proteomic. metabolomic. setaria viridis 
ProteomicsProteome analysis of Escherichia coli ptsN-null strain under different nitrogen regimes
The carbohydrate-uptake phosphorelay PTS system plays a key role in metabolic regulation in Bacteria controlling the utilization of secondary carbon sources. Some Bacteria, such as Escherichia coli, encode a paralogue system named PTSNtr (nitrogen related PTS). PTSNtr is composed of EINtr (ptsP), NP...
ORGANISM(S): Escherichia coli 
2018-09-13 | PXD008034 | Pride
Pts Ntr Nitrogen Proteome Pii 
ProteomicsThe PII protein-protein interaction network in Azospirillum brasilense reveals a novel role of PII in the control of c-di-GMP homeostasis
The PII family comprises a group of widely distributed signal transduction proteins ubiquitous present in prokaryotes and in the chloroplast of plants. The PII proteins sense the levels of key metabolites ATP, ADP and 2-oxoglutarate which affect the PII structure and the ability of PII to interact w...
ORGANISM(S): Azospirillum brasilense Sp245 
2020-10-23 | PXD018530 | Pride
C-di-gmp Protein interaction Motility Pii protein Metabolic regulation 
ProteomicsmicroRNA-140 inhibits inflammation and stimulates chondrogenesis in a model of IL1β-induced osteoarthritis
Osteoarthritis is a devastating disease of articular cartilage. The pathogenic factors contributing to this disorder are inflammation, extracellular matrix degradation and failure to rebuild the articular cartilage. Preclinical studies suggest that microRNA-140 (miR-140) may play a protective role i...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003362 | Pride
Il1b Osteoarthritis Microrna-140 Inflammation Articular cartilage 
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo sapiens (Human) 
2016-05-10 | PXD002678 | Pride
Lc-msms Celiac disease Gliadin Monoclonal antibodies Epitopes 
ProteomicsThe phosphatase PTPRG controls FGFR1 activity and influences sensitivity to FGFR kinase inhibitors
Recently, FGFR1 has been found to be overexpressed in osteosarcoma and thus represents an important target for precision medicine. However, because targeted cancer therapy based on FGFR inhibitors has so far been less efficient than expected, a detailed understanding of the target is important. We h...
ORGANISM(S): Homo sapiens (Human) 
2018-01-29 | PXD006157 | Pride
Protein interaction Mass spectrometry Ptprg Fgfr1 
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