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GenomicsTranscriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
Transcriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
PRJNA686431 | ENA
TranscriptomicsTranscriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
Shank3 protein is a core organizer of the macromolecular complex in excitatory postsynapses, and its defects cause numerous synaptopathies including autism spectrum disorders. Although Shank3 function as a postsynaptic scaffold is well established, other potential mechanisms how Shank3 broadly modul...
ORGANISM(S): Mus musculus 
2023-12-18 | GSE163528 | GEO
UnknownIncreased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice.
Not available
S-EPMC7903774 | biostudies-literature
ProteomicsSynaptosome proteome IGF2 enhancer knockout mice
We identified an enhancer element near IGF2 locus that is possibly involved with dopamine function and schizophrenia. A knockout mouse was generated for the enhancer element in the IGF2 locus. We then characterized the striatal synaptosomes ( i.e. biological fraction representing pre- post synaptic ...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-31 | PXD012786 | Pride
Dopamine Schizophrenia Striatum Synaptosome Igf2 
ProteomicsThe proteomic landscape of synaptic diversity across brain regions and cell types
Brain function relies on communication via neuronal synapses. Neurons build and diversify synaptic contacts using different protein combinations that define the specificity, function and plasticity potential of synapses. More than a thousand proteins have been globally identified in both pre- and po...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-30 | PXD039946 | Pride
Synapse Fass Synaptosomes 
ProteomicsDisruption of LRRK2 Activator RAB12 Facilitates Neurotransmission and Causes Hyperactivity in Mice
RAB12 is a family member of small GTPases best known as a physiological substrate of LRRK2 kinase, the variants of which cause Parkinson’s disease (PD). RAB12 - LRRK2 interaction is crucial for the activation of LRRK2 kinase activity and pathogenic signaling in ciliogenesis and immune response. Howe...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-29 | PXD075183 | Pride
Parkinson’s disease  lrrk2  rab12 ko  mouse  proteomics striatal synaptosome 
UnknownAlpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction.
Not available
S-EPMC9323501 | biostudies-literature
ProteomicsProteome of mouse striatal dopamine synaptosomes purified by fluorescence sorting
Dopamine transmission is a monoaminergic system involved in reward processing and motor control. Volume transmission is thought to be the main mechanism by which monoamines modulate effector transmission though synaptic structures are scarcely described. In the present work we aimed to unravel the c...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD027534 | Pride
Synapse Dopamine Striatum Fass Synaptosome Mouse Proteome 
ProteomicsProteomics analysis of dorsal striatum reveals changes in synaptosomal proteins following ethamphetamine self-administration in rats
Methamphetamine is a widely abused, highly addictive drug. Regulation of synaptic proteins within the brain’s reward pathway modulates addiction behaviours, the progression of drug addiction and long-term changes in brain structure and function that result from drug use. Therefore, using large scale...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2015-05-06 | PXD001443 | Pride
Lc-ms/ms Rat Shotgun proteomics Synaptosome 
ProteomicsLoss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to anormal motor behavior and synaptic defects
Mutations in PARK15, which encodes for the F-box protein FBXO7 have been associated with Parkinsonian Pyramidal syndrome, a rare and complex movement disorder with Parkinsonian symptoms, pyramidal tract signs and juvenile onset. Our previous study showed that systemic loss of Fbxo7 in mice causes mo...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-18 | PXD044119 | Pride
Brain Lc-ms Mouse Synapse 
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