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ProteomicsBRD9 regulates leukemic cell survival via STAT5 pathway inhibition
Leukemia is characterized by genetic and epigenetic mutations resulting in selection of cancer stem cells, which are unable to differentiate. While genetic alterations are difficult to target, the epigenome is intrinsically dynamic and readily offers new therapeutic strategies. Thus, identifying can...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013245 | Pride
Lc-msms Stat5 Leukemia Brd9 
ProteomicsThe HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia
Leukemias are characterized by bone marrow failure due to oncogenic mutations of hematopoietic stem cells (HSC) or blood precursor cells. HSC differentiation and self-renewal properties are tightly regulated by Polycomb group (PcG) proteins, a well-characterized family of transcriptional epigenetic ...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD008287 | Pride
Saha Sumoylation Leukemia Cbx2 
ProteomicsIP-MS of LSD1 and ER in treated Breast cancer cells
These proteomic data were produced in order to assess the effect of drug 3324, a pan-lysine demethylase inhibitor, on the estrogen receptor (ER) and Lysine Demethylase1 (LSD1)protein interaction networks.
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012781 | Pride
Human Breast cancer Pulldown Estrogen receptor Lysisne deaminase 
ProteomicsCharacterization of AR interactome in prostate cancer cells after MC3324 treatment
We here investigated the alterations in the androgen receptor (AR) itneractome after treatment with the dual-KDM inhibitor MC3324.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029249 | Pride
Prostate cancer Interactome Androgen receptor 
ProteomicsProteomic characterization of Prostate cancer cell lines
Proteomic characterization of prostate cancer cell lines after drug treatment.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029525 | Pride
Proteomics Mass spectrometry Label-free Prostate cancer 
TranscriptomicsTranscriptome analysis of mouse embryonic stem cells treated with MS-275
This study describes transcriptome profiling of mouse ES cells treated with MS-275. We included RNA-Seq of ds_cDNA synthesized from double poly(A) selected mRNA RNA-Seq profiling on mouse ES cells treated with MS-275
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-45909 | biostudies-arrayexpress
GenomicsOncofusion protein AML1-ETO targets ERG factor binding sites in AML
ERG has been identified as an essential factor for the function and maintenance of adult hematopoietic stem cells and high ERG expression is a negative prognostic marker for treatment outcome in AML. The molecular function of ERG and its interplay with other factors is however largely unknown. Here ...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-23730 | biostudies-arrayexpress
GenomicsPML-RARa/RXR alters the epigenetic landscape in Acute Promyelocytic Leukemia
Many different molecular mechanisms have been suggested to be associated with PML-RAR dependent transformation of haematopoietic progenitors. Here, we investigated the role of PML-RAR and RXR in the organization of epigenetic structures at a genome-wide level. We identified 2722 high confidence PML-...
ORGANISM(S): Homo sapiens 
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
GenomicsComparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues
In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions in 24 tumor and matched normal colon samples. In total, 2687 frequently hypermethylated and 468 frequently hypomethylated regions were identified, which include potent...
ORGANISM(S): Homo sapiens 
2012-10-26 | E-GEOD-39068 | biostudies-arrayexpress
TranscriptomicsAssessment of low-dose BPA toxicity in thyroid follicular cells by gene expression microarray.
Gene expression microarrays were performed to investigate the molecular effects of exposure to BPA on thyrocytes (FRTL-5). Cells were treated with low-lose BPA (10^-9 M) at different time points to analyse time dependent toxicity.
ORGANISM(S): Rattus norvegicus 
2016-02-29 | E-MTAB-4458 | biostudies-arrayexpress
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