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MetabolomicsIdentifying metabolic alterations associated with coral growth anomalies using 1H NMR metabolomics
Coral growth anomalies (GAs) are tumor-like protrusions that are detrimental to coral health, impacting both the coral skeleton and soft tissues. These lesions are increasingly found throughout the tropics and are commonly associated with high human population density, yet little is known about the ...
2021-06-15 | MTBLS2424 | MetaboLights
ProteomicsDeletion of GSE1 and HDAC1 inactivation alters proteomic profiles and cell cycle control
The DNA damage response (DDR) is orchestrated by multiple, tightly regulated signalling events. We discovered that genetic suppressor element 1 (GSE1) forms a complex with the histone deacetylation 1 (HDAC1) / CoREST complex and that loss of GSE1 hampers DDR induction. To investigate how GSE1 and HD...
ORGANISM(S): Homo sapiens (Human) 
2023-10-23 | PXD040339 | Pride
Acetylome Hdac1 Gse1 Phosphorylome Hap1 Dna damage response 
UnknownNatural variation in yolk fatty acids, but not androgens, predicts offspring fitness in a wild bird.
Not available
S-EPMC8340462 | biostudies-literature
ProteomicsGSE1 is a prominent interactor of HDAC1
We analysed the composition of histone acetylase 1 (HDAC1)-associated proteins in different cellular backgrounds using quantitative mass spectrometry (MS). First, we affinity purified (AP) C-terminally FLAG-tagged HDAC1 from the nearly haploid human cell line HAP1 (Andersson et al, 1987). To examine...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-10-23 | PXD040307 | Pride
Mef Hdac1 Gse1 Hap1 Dna damage response Interactome 
ProteomicsProteomic analysis of distal cholangiocarcinoma
Distal cholangiocarcinoma is an aggressive malignancy with a dismal prognosis. There is a lack of diagnostic and prognostic biomarkers. An improved understanding of proteomic changes associated with malignancy and identification of potential biomarkers can help improve the survival of patients. A wo...
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD017906 | Pride
Prm Bile duct cancer Cholangiocarcinoma Lc-ms/ms 
UnknownEndosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale.
Not available
S-EPMC8666849 | biostudies-literature
UnknownWell-based crystallization of lipidic cubic phase microcrystals for serial X-ray crystallography experiments.
Not available
S-EPMC6779076 | biostudies-literature
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Homo sapiens (Human) 
2026-04-17 | PXD069216 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-17 | PXD069221 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
ProteomicsThe C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit corepressor complexes, thereby targeting distinct sets of genes. Here, we identify C16orf8...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-17 | PXD069222 | Pride
Hdac1 Mier1 Migration C16orf87 Chromatin Embryonic development 
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