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TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
ProteomicsProteome landscape of schizophrenia in patient-derived cerebral organoids
We utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD027812 | Pride
Schizophrenia Ipsc Proteome Cerebral organoids Neuropathology 
ProteomicsHeart tissue extracellular vesicles reprogram smooth muscle cell proteome
Dysregulation of ERalpha has been linked with increased metabolic and cardiovascular disease risk. Uncovering the impact of ERα deficiency in specific tissues has implications for understanding the role of ERα in normal physiology and disease, the increased disease risk in postmenopausal women, and ...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-15 | PXD038482 | Pride
Cardiac Proteomics Extracellular vesicles Systems biology Cell reprogramming 
ProteomicsCardiomyocytes regulate cardiac fibroblast activation and oxidative stress via CK2 signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGFβ induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, with dy...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD038854 | Pride
Cardiac fibroblasts Cardiomyocytes Proteomics Ck2 Signaling 
ProteomicsiPSC nanovesicles cardiac cell repair
Here, we engineered functional EV-like nanovesicles (NVs) from human-induced pluripotent stem cells and highlight their potential as a functional surrogate for natural EVs for tissue repair. Proteome profiling of target cells further identified pathways implicated in angiogenesis (MYH10, AAMP, SLC3A...
ORGANISM(S): Homo sapiens (Human) 
2023-01-15 | PXD036654 | Pride
Proteomics Ipsc Nanovesicles Cardiac repair Cell reprogramming 
MetabolomicsSex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic consequences of loss of Cd248. Strikingly, we find these to be sex speci...

2023-01-05 | MTBLS6615 | MetaboLights
ProteomicsHeart-derived extracellular vesicles reprogram smooth muscle cells
Dysregulation of ER has been linked with increased metabolic and cardiovascular disease risk. Uncovering the impact of ERα deficiency in specific tissues has implications for understanding the role of ERα in normal physiology and disease, the increased disease risk in postmenopausal women, and the d...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-15 | PXD033078 | Pride
Heart Extracellular vesicles Proteome Reporgram Muscle 
ProteomicsMesenchymal stem cell-derived extracellular vesicles
Therapeutic benefits of mesenchymal stem/stromal cells (MSCs) are now widely believed to come from their paracrine signalling, i.e. secreted factors such as cytokines, chemokines, and extracellular vesicles (EVs). Cell-free therapy using EVs is an active and emerging field in regenerative medicine. ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD029766 | Pride
Mesenchymal stem cell Culture Lung fibrosis Extracellular vesicles 
Proteomicstherapeutic CD14 heart proteome
Therapeutic remodelling and repair of murine heart induced by CD14 antibody treatment. Global (apex) heart and macrophage-derived (FACS) proteome remodelling of CD14 antibody-based therapeutic.
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD041192 | Pride
Mouse Macrophage Cd14 Therapeutic Proteome Repair 
ProteomicsUnstable Atherosclerotic Plaque Proteome
The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, is a major health burden worldwide. Limited understanding as to the molecular drivers of plaque instability and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Utilisin...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD030857 | Pride
Atherosclerosis Therapeutic Mouse Plaque Proteome 
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