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ProteomicsLC-MSMS analysis of HFF1 cells exposed to bear and bovine serum
The serum of hibernating bears has been shown to exhibit cytoprotective, anticatabolic effects when applied to human or mouse skeletal muscle cells. It is also able to reduce mitochondrial respiration in cells obtained from bear adipose tissue. Its action notably might involve reprogramming of trans...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD069199 | Pride
Serum Hibernation Quantitative proteomics Fibroblast 
ProteomicsLC-MSMS analysis of ageing vs labour division in ants
In social insects, workers perform distinct tasks according to the caste they belong to, and workers from different castes differ in their age (nest workers are usually younger than foragers are). The caste shift thus seems inseparable from age, preventing from deciphering the role of labour divisio...
ORGANISM(S): Lasius niger 
2023-03-11 | PXD026565 | Pride
Lc-msms Ant Ageing Sociality 
ProteomicsMouse cerebellum LC-MSMS: effect of calorie restriction
The cerebellum harbors a circadian clock that can be shifted by scheduled mealtime and participates in behavioral anticipation of food access. To determine which cerebellar proteins are modified by time-of-day and/or feeding time, we determined day-night variations of proteome in the cerebellum of m...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-06 | PXD021056 | Pride
Lc-msms Circadian rhythm Mouse Cerebellum 
ProteomicsAnt LC-MSMS
Animal longevity widely differs across species, and even individuals from the same species may exhibit different rates of ageing. In different species, the rate at which individuals actually age is related to the level of their social interactions, but this was still not known in ants. In a given co...
ORGANISM(S): Lasius niger 
2020-08-03 | PXD006779 | Pride
Lc-msms Ant Longevity Sociality 
ProteomicsCircadian analysis of the mouse cerebellum
The cerebellum contains a circadian clock, generating internal temporal signals. The daily oscillations of cerebellar proteins were investigated here in mice using large-scale two-dimensional differences in gel electrophoresis (2D-DIGE). Analysis of 2D-DIGE gels highlighted the rhythmic variation in...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-23 | PXD013039 | Pride
Lc-msms Circadian rhythm Mouse Cerebellum 
ProteomicsMouse spleen LC-MSMS: effects of age and immune challenge
Ageing is characterized by the progressive lowering of the acute innate immune response and the progressive up-regulation of low-grade inflammation (i.e. inflammaging). At the cellular level, telomeres are considered as a mark of ageing as their length is progressively shortened. However, the links ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-12 | PXD009005 | Pride
Lps Lc-msms Mouse Ageing Spleen 
ProteomicsPenguin plasma LC-MSMS - The Safety Limits Of An Extended Fast: Lessons from a Non-Model Organism
While safety of fasting therapy is debated in humans, extended fasting occurs routinely and safely in wild animals. To do so, food deprived animals like breeding penguins anticipate the critical limit of fasting by resuming feeding. To date, however, no molecular indices of the physiological state t...
ORGANISM(S): Pygoscelis adeliae 
2017-01-02 | PXD004808 | Pride
Lc-msms Adélie penguin Plasma 2d gels 
ProteomicsRat white adipose tissue DIGE-LC-MSMS
White adipose tissue is a central place to energy storage and a major endocrine organ. However, adipose molecular mechanisms have been poorly studied during prolonged fasting. To fill this gap, the aim of this study was to decipher proteomic regulations in rat adipose tissue during phase 2 (lipid mo...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-02-24 | PXD010902 | Pride
Lc-msms Rat Fasting White adipose tissue 2d-dige 
ProteomicsMouse muscle LC-MSMS upon weightlessness
Upon weightlessness and microgravity, deleterious effects on the neurosensory and neurovestibular systems, haematological changes, and deconditioning of musculoskeletal, cardiovascular and cardiopulmonary functions have been reported. In particular, loss of muscle mass and strength are triggered by ...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-14 | PXD005035 | Pride
Lc-msms Muscles Mice Spaceflight 
ProteomicsLC-MSMS analysis of muscle in the gilt-head sea bream depending on pollutant levels
The oceans are now all affected by human activities. The study of the impact of pollution on the health status of exploited marine populations is essential to better understand the direct constraints that stress generates on growth, reproduction, immune system and, ultimately, on the reproductive su...
ORGANISM(S): Sparus aurata 
2025-03-17 | PXD037412 | Pride
Fish Health biomarker Pollution Quantitative proteomics 
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