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ProteomicsStructural Host Virus Interactome Profiling of Intact Infected Cells
Virus-host protein-protein interactions (PPIs) are fundamental to viral infections, yet high-resolution identification within the native context of intact infected cells has remained an unsolved challenge. Here, we developed structural host-virus interactome profiling (SHVIP) that combines in situ c...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2025-06-13 | PXD047422 | Pride
Virus Ppi Hsv-1 Xl-ms Shvip Herpes 
ProteomicsCross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
Herpesviruses encode conserved protein kinases to optimize virus infection by targeted phosphorylation. How these kinases bind to cellular factors and how this impacts their regulatory functions is poorly understood. Here, we use quantitative proteomics to determine the interactomes of eight herpesv...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Herpesvirales 
2020-08-13 | PXD016334 | Pride
Hcmv Ebv Conserved herpesvirus protein kinases Hsv-1 Mcmv 
ProteomicsInteraction of Human Cytomegalovirus pUL52 with major components of the viral DNA encapsidation network underlines its essential role in genome cleavage-packaging
Cleavage of human cytomegalovirus (HCMV) genomes and their packaging into capsids requires at least seven essential viral proteins, yet it is not completely understood how these proteins cooperate to accomplish this task. Besides the portal protein pUL104 and the terminase subunits pUL51, pUL56, and...
ORGANISM(S): Homo sapiens (Human) Human cytomegalovirus (HHV-5) (Human herpesvirus 5) 
2025-02-17 | PXD060825 | Pride
Interaction proteomics Pul52 Terminase Human cytomegalovirus 
ProteomicsThe dynamic proteome of Influenza A virus infection
We combined metabolic pulse labeling and quantitative shotgun proteomics to globally monitor protein synthesis upon infection of human cells with a human- and a bird-adapted IAV strain. While production of host proteins was remarkably similar, we observed striking differences in the kinetics of vira...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD011321 | Pride
Influenza Protein de novo synthesis Aha A549 Silac Avian flu Human flu 
ProteomicsThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
A century ago, influenza A virus (IAV) infection caused the 1918 flu pandemic and killed an estimated 20-40 million people. Pandemic IAV outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular details of this species barrier are incomp...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD015474 | Pride
Influenza a virus Human Avian Newly synthesized proteins 
ProteomicsThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
A century ago, influenza A virus (IAV) infection caused the 1918 flu pandemic and killed an estimated 20-40 million people. Pandemic IAV outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular details of this species barrier are incomp...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2019-11-11 | PXD015475 | Pride
Influenza a virus infection 
ProteomicsCloning and Decoding of Chimpanzee Cytomegalovirus - A Resource for Comparative Functional Genomics
The chimpanzee cytomegalovirus (CCMV) is the closest relative of human CMV (HCMV). Because of the high conservation between these two species and the ability of human cells to fully support CCMV replication, CCMV holds great potential as a model system for HCMV. To make the CCMV genome available for...
ORGANISM(S): Panine betaherpesvirus 2 Homo sapiens (Human) 
2021-12-20 | PXD027434 | Pride
Cytomegalovirus Decoding Evolution Chimpanzee 
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