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ProteomicsQuantitative Secretome Analysis of Activated Jurkat Cells
A quantitative label-free secretome analysis protocol using a click chemistry-based approach for the enrichment of secreted glycoproteins was adapted for and applied to a T cell model. There, Jurkat cells were activated via PMA/ionomycin and the dynamic modulation of the T cell secretome was investi...
ORGANISM(S): Homo sapiens (Human) 
2016-10-10 | PXD004280 | Pride
T cell model Jurkat Quantitative label-free lc-ms/ms Secretome 
ProteomicsComparative proteome and serum analysis identified FSCN1 as a marker of abiraterone resistance in castration-resistant prostate cancer
Background: Abiraterone (Abi) is an androgen receptor signaling inhibitor that significantly improves patients' life expectancy in metastatic prostate cancer (PCa). Despite its beneficial effects, many patients have baseline or acquired resistance against Abi. Objective: To identify predictive seru...
ORGANISM(S): Homo sapiens (Human) 
2023-08-28 | PXD038697 | Pride
Abiraterone Fscn1 Prostate cancer Amacr Ctag1a Biomarker Klk2 
ProteomicsDifferential interferon-α subtype immune signatures suppress SARS-CoV-2 infection
Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control versus immune-mediated pathologies and have been successfully employed for the treatment of viral diseases. Humans express twelve IFN-alpha (α) subtypes, which activate downstream signall...
ORGANISM(S): Homo sapiens (Human) 
2022-02-09 | PXD026079 | Pride
Isg Sars-cov-2 Antiviral treatment Therapy Covid-19 Type i ifn Ifnα subtypes 
ProteomicsPlasma proteomics enable differentiation of lung adenocarcinoma from chronic obstructive pulmonary disease (COPD)
Background: Chronic obstructive pulmonary disease (COPD) is a major risk factor for the development of lung adenocarcinoma (AC). AC often develops on underlying COPD, thus the differentiation of both entities by biomarker is challenging. Although survival of AC patients strongly depends on early dia...
ORGANISM(S): Homo sapiens (Human) 
2022-10-17 | PXD035120 | Pride
Machine learning Random forest Serpina3 Saa1 Chronic obstructive pulmonary disease Artificial intelligence Adenocarcinoma of the lung Plasma proteomics 
ProteomicsHepatocyte-specific BIRC5 (Survivin)-knockout-mouse model, Subcellular fractionation
Experimental design For the label-free proteome analysis 17 mice were used composed of 5 individual wildtype mice for each condition before (WTprePHE) and after hepatectomy (WTpostPHE). For the pre-hepatectomy condition four BIRC5-knockout mice (KOprePHE) were analyzed and three individuals after p...
ORGANISM(S): Mus musculus (Mouse) 
2014-05-22 | PXD000625 | Pride
Liver regeneration Birc5 Knockout Mouse Survivin Liver 
ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026876 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
ProteomicsProteomics characterization of NTRK1/TrkA signaling in neuroblastoma cells reveals intra-nuclear aggregation of Lamin A/C
Simple Summary: Neuroblastoma (NB) accounts for 15% of all cancer related deaths of children. While amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB, expression of the neurotrophin receptor, NTRK1/TrkA, has been shown to associate with an excellent outcome. MYCN down-regulate...
ORGANISM(S): Homo sapiens (Human) 
2021-11-11 | PXD026913 | Pride
Neuroblastoma Mycn Nuclear foci Trka Ntrk1 
ProteomicsQuantitative proteome analysis of plasma microparticles for characterization of HCV-induced hepatic cirrhosis and hepatocellular carcinoma
A quantitative label-free proteome analysis was performed using plasma samples from 22 hepatitis-C virus (HCV)-induced liver cirrhosis patients, 16 HCV-positive hepatocellular carcinoma patients with underlying cirrhosis and 18 healthy controls. Plasma microparticles (PMPS) were isolated using ultra...
ORGANISM(S): Homo sapiens (Human) 
2017-06-21 | PXD005777 | Pride
Plasma microparticles Liver cirrhosis Hepatitis c virus Label-free proteomics Hepatocellular carcinoma 
ProteomicsPlasma proteomics identifies molecular subtypes in sepsis
Background The heterogeneity of sepsis represents a major problem for the development of personalized sepsis therapies. Thus, sepsis subtyping emerged as an important tool to approach this problem, but little progress was made due to insufficient molecular insights. Modern proteomics techniques allo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD064125 | Pride
Machine learning Precision medicine Subclasses Plasma Hierarchical clustering Sepsis Clinical routine data 
ProteomicsMachine learning identifies clinical sepsis phenotypes that translate to the plasma proteome
Background: Sepsis therapy is still limited to the treatment of the underlying infection and supportive measures. Therapeutic options that address the molecular changes of sepsis have not yet been identified. With the aim of a future individualized therapy, we used unsupervised machine learning (ML)...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD058562 | Pride
Mass spectrometry Precision medicine Artificial intelligence Plasma Cluster analysis 
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