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TranscriptomicsRNA-seq of A431 cell line after gefitinib treatment
RNA sequencing of A431 cell line samples before and after gefitinib treatment, at 0, 2, 6 and 24 hours, was performed in order to characterize the cell line's early and late response to this drug, and to compare against proteomics (mass spectrometry) characterization of the cell line using the same ...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5285 | biostudies-arrayexpress
UnknownStructural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor.
Not available
S-EPMC4646176 | biostudies-literature
ProteomicsDOPA formation on tyrosine Y150 of Ribonucleotide reductase QSK R2e variant from Gardnerella vaginalis.
With a crystal structure and mass spectrometry on recombinantly expressed and purified Ribonucleotide reductase QSK R2e variant from Gardnerella vaginalis we show that this protein has a modified DOPA (3,4-Dihydroxy-L-phenylalanine) in the active site analogous to what was observed for the VPK varia...
ORGANISM(S): Gardnerella vaginalis 
2023-09-08 | PXD045227 | Pride
Qexactive hf 3 Ptm Gardnerella vaginalis 4-dihydroxyphenylalanine Tyrosine Ribonuclotide reductase Dopa 
ProteomicsImmediate adaption – Quantitative Proteomics of BCL6 silencing and EGFR TK inhibition
We aimed to identify the response mechanism to EGFR tyrosine kinase inhibition. A431 cells were transfected with mock siRNA or BCL6 siRNA. Cells were then treated with gefitinib. Harvesting was done at 0h, at 24h and at 48h. Two TMT10plex sets were organized as follows: TMT set1: mock 0h (3x, channe...
ORGANISM(S): Homo sapiens (Human) 
2020-12-09 | PXD016605 | Pride
Human Bcl6 sirna Tmt proteomics Lc-ms Time course Egfr inhibition Gefitinib A431 cells 
ProteomicsProteomics of U1810 cells upon treatment with microRNAs with an AAGUGC seed motif.
microRNA dysregulation is a common feature of cancer cells, but the complex roles of microRNAs in cancer are not fully elucidated. Here we used functional genomics to identify oncogenic microRNAs in non-small cell lung cancer and to evaluate their impact on response to EGFR targeting therapy. Our da...
ORGANISM(S): Homo sapiens (Human) 
2016-06-28 | PXD004163 | Pride
Human Mirna Lc-ms Microrna U1810 Hirief 
ProteomicsImpact of whole-body versus nose-only exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model [Lung data]
The objective of this study was to compare the biological and toxicological response of apolipoprotein E-deficient (Apoe-/-) mice to 3R4F mainstream smoke exposure for 2 months in whole-body exposure chambers (WBEC) and nose-only exposure chambers (NOEC). Female ApoE-/- mice were randomized into fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-26 | PXD018185 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsA 7-month e-vapor aerosol inhalation toxicology study in C57BL/6 mice [Lung data]
A 7-month inhalation study in C57BL/6 mice was conducted to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation or switching to an e-vapor product after 3 months of exposure to 3R4F cigarette smoke (CS). In this study,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-31 | PXD019918 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsHuman Lung cancer proteomics and proteogenomics LC/MS&MS
In this project, a cohort of early stage NSCLC samples (141) were analyzed by MS-based proteomics in order to identify molecular subtypes at the phenotype level. In total, close to 14 000 proteins were identified and quantified across samples by HiRIEF-LC-MS and TMT based relative quantification. Fu...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD020191 | Pride
Proteogenomics Proteomics Lung cancer Adenocarcinoma 
UnknownCharacterization of a second class Ie ribonucleotide reductase.
Not available
S-EPMC11846895 | biostudies-literature
Proteomics,MultiomicsProteomics of U1810 cells upon treatment with microRNAs with an AAGUGC seed motif.
microRNA dysregulation is a common feature of cancer cells, but the complex roles of microRNAs in cancer are not fully elucidated. Here we used functional genomics to identify oncogenic microRNAs in non-small cell lung cancer and to evaluate their impact on response to EGFR targeting therapy. Our da...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080829 | MassIVE
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