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ProteomicsGlobal analysis of neuropeptides in cestodes identifies Attachin, a SIFamide homolog, as a stimulant of parasite motility and attachment
Many anthelmintics target the neuromuscular system, in particular by interfering with signalling mediated by classical neurotransmitters. Although peptidergic signalling has been proposed as a target of novel anthelmintics, current knowledge of the neuropeptide complement of many helminths is still ...
ORGANISM(S): Hymenolepis microstoma 
2022-06-13 | PXD033611 | Pride
Peptidomics Sucker Motility Peptidergic Sifamide Tapeworm 
TranscriptomicsIRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development [ChIP-chip]
Interferon regulatory factor 4 (IRF4) is a master transcription factor required for the maturation of germinal center B cells that eventually develop into antibody secreting plasma cells and memory B cells. IRF4-deficient mice exhibit a profound reduction in serum immunoglobulin levels. In spite of...
ORGANISM(S): Homo sapiens 
2015-12-15 | E-GEOD-64268 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics links glutathione to bacterial cell cycle progression
Cell cycle progression requires the coordination of cell growth, chromosome replication, and division. Consequently, a functional cell cycle must be coupled with metabolism. However, direct measurements of metabolome dynamics remained scarce, in particular in bacteria. Here, we describe an untargete...
2020-10-15 | MTBLS1402 | MetaboLights
ProteomicsHSF1-interacting proteins in control and heat shock conditions
HeLa cells were treated or untreated with heat shock at 42°C for 5, 30, and 60 min, and were then fixed in medium containing 1% formaldehyde at 37°C for 30 min. Chromatin fraction was sonicated with the Branson Sonifier 450 (BRANSON Ultrasonics) into fragmented DNA around 200-300 bp. HSF1 bound to g...
ORGANISM(S): Homo Sapiens (human) 
2022-06-19 | PXD031821 | JPOST Repository
ProteomicsPhosphoproteome, ubiquitinome and full proteome analysis at 6 and 24 hours post SARS-CoV-2 infection in A549-ACE2 cells
A549-ACE2 cells were mock or SARS-CoV-2 infected (multiplicity of infection: 3) for 6 or 24 h and subjected to full proteome, phosphoproteome and ubiquitinome analysis using data-dependent acquisition LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD020019 | Pride
Sars-cov-2  infected proteome  phosphoproteome  ubiquitinome  a549-ace2 
ProteomicsSyntaxin-3 is a Weibel-Palade body localized SNARE protein that regulates Von Willebrand factor secretion from endothelial cells
Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously identified STXBP1 as the link between the Rab27A-Slp4-a ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD006176 | Pride
Endothelial cells Proteomics Weibel-palade body Snare machinery Syntaxin-3 Von willebrand factor 
ProteomicsDynamic proteomics reveals unexpected plasticity of cellular proteome: growth-related and drug-induced changes in cancer cells are comparable
In proteomics, the changes occurring in cellular proteomes upon drug treatment are used to identify the drug targets and the mechanism of action. However, proteomes of cultured cells undergo also natural alteration associated with changes in the media, attaining a degree of confluence as well as due...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD007762 | Pride
Fitexp  mass spectrometry  proteomics  principal component analysis  time series 
ProteomicsComprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to ai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016776 | Pride
Cancer Nfkb2 Mass spectrometry Hct116 Thioredoxin reductase Expression Chordc1 Database A375 Drug Proteomics Resource Rko Chemotherapeutic Auranofin Compound 
UnknownCancer drug sensitivity prediction from routine histology images.
Not available
S-EPMC10771481 | biostudies-literature
ProteomicsPattern Analysis of Organellar Maps for Interpretation of Pro-teomic Data
The human proton-coupled folate transporter (PCFT) was stably expressed as a fu-sion protein with a BioID2-HA in the C-terminal position (PCFT-BioID2). The uncom-plxed biotin transferase was used as a control to identify proteins that are biotinylated randomly due to sheer abundance and/or an unnatu...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032297 | Pride
Proteomics  pattern analysis  bioinformatics  proximity labeling 
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