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ProteomicsMus musculus brown adipose tissue histone proteoforms
Histones were isolated from brown adipose tissue and liver from mice housed at 28, 22, or 8 C. Quantitative top- or middle-down approaches were used to quantitate histone H4 and H3.2 proteoforms. See published article for complimentary RNA-seq and RRBS datasets.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-05 | MSV000092105 | MassIVE
Proteomics2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Mitochondria play a crucial role in regulating cellular homeostasis in response to intrinsic and extrinsic cues by changing cellular metabolism to meet these challenges. However, the molecular underpinnings of this regulation and the complete spectrum of these physiological outcomes remain largely u...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD064288 | Pride
Nuclear softening Brown adipose tissue Mitochondria 2-hydroxyglutarate 
ProteomicsComparative secretome analysis of primary murine white and brown adipocytes
The adipose organ, including white and brown adipose tissues, is an important player in systemic energy homeostasis, storing excess energy in form of lipids while releasing energy upon various energy demands. Recent studies have demonstrated that white and brown adipocytes also function as endocrine...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-04 | PXD009280 | Pride
Brown adipocytes Adrenergic stimulation White adipocytes Secretome Murine svf cells 
UnknownRNAseq-Based Carboxylesterase <i>Nl-EST1</i> Gene Expression Plasticity Identification and Its Potential Involvement in Fenobucarb Resistance in the Brown Planthopper <i>Nilaparvata lugens</i>.
Not available
S-EPMC11508480 | biostudies-literature
ProteomicsFAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes
Cold stimulation dynamically remodels mitochondria in brown adipose tissue (BAT) to facilitate non-shivering thermogenesis in mammals, but what regulates mitochondrial plasticity is poorly understood. Comparing mitochondrial proteomes in response to cold identify FAM210A as a cold-inducible mitocho...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-26 | PXD044866 | Pride
Lc-msms Mouse Brown adipocyte Cold Brown fat Mitochondria Fam210a 
ProteomicsTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposureTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposure
The proteome cargo of extracellular vesicles released from brown adipose tissue (BAT) and from white adipose tissue (WAT) of mice subjected to cold exposure (4°C) was analysed by a TMT-based quantitative proteomic procedure in order to obtain new information on the processes of thermogenesis.
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD026080 | Pride
Tmt Lc-ms Bat/wat Evs 
ProteomicsBrown bear skeletal muscle quantitative LC-MSMS
Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bear...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2019-05-14 | PXD004908 | Pride
Lc-msms Skeletal muscle Hibernation Bears 
ProteomicsQuantitative proteomics of brown bear muscle during hibernation
During hibernation, the physiology of bears is characterized by strong metabolic depression. In skeletal muscles, lipids are used as the main energy fuels although their oxidation rate is reduced, and glycolysis appears maintained likely feeding the Cori cycle. For a better knowledge on proteome rem...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2026-03-02 | PXD060503 | Pride
Lc-msms Metabolic depression Bear Hibernation Muscle 
MetabolomicsSearching for metabolic changes in urine headspace composition as an effect of strenuous walking
The present investigation uses proton transfer reaction mass spectrometry (PTR-MS) combined with multivariate and univariate statistical analyses to study potential biomarkers for altered metabolism in urine due to strenuous walking. Urine samples, in concurrence with breath and blood samples, were ...
2016-12-14 | MTBLS164 | MetaboLights
ProteomicsDifferent SWI/SNF complexes coordinately promote R-loop- and RAD52- dependent transcription-coupled homologous recombination
The SWI/SNF family of ATP-dependent chromatin remodeling complexes are implicated in multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF and PBAF complexes are two major types of SWI/SNF complexes that are functionally distinguished by their exclusive subunits. Accumula...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD035140 | Pride
Swi/snf  transcription-coupled homologous recombination  r-loops  rad52  dna damage response  arid1a  arid1b  brg1  brm 
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