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ProteomicsSystematic quantitative analysis of H2A and H2B variants by targeted proteomics
Background: Histones organize DNA into chromatin through a variety of processes. Among them, a vast diversity of histone variants can be incorporated into chromatin to finely modulate its organization and functionality. Classically, the study of histone variants has largely relied on antibody-based ...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-16 | PXD008358 | Pride
Srm Prm Histone variants Targeted proteomics Spermatogenesis Chromatin Proteomics 
ProteomicsProteomic characterization of human exhaled breath condensate
The establishment and public sharing of comprehensive proteome maps of human tissues and biofluids are essential to improve biomedical knowledge and to support biomarker discovery studies. In this study, we performed an in-depth proteomics characterization of the exhaled breath condensate (EBC), a n...
ORGANISM(S): Homo sapiens (Human) 
2017-12-06 | PXD007591 | Pride
Exhaled breath condensate Homo sapiens Nanolc-ms/ms 
ProteomicsProteomics exploration of the Atp7b-/- mouse plasma proteome: translational relevance for the diagnosis of Wilson’s disease
Wilson’s disease (WD) is a rare genetic disease caused by mutations in the ATP7B gene. These mutations impact the expression and/or function of the copper-transporting ATP7B protein, leading to massive toxic accumulation of copper in the liver and brain. Due to its low incidence and highly variable ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-04-14 | PXD011007 | Pride
Lc-srm Liver Biomarkers Wilson's disease Nanolc-ms/ms 
ProteomicsPepS: a microfluidic device to process whole blood at bedside for plasma proteomic analyses
Immunoassays have been used for decades in clinical laboratories to quantify proteins in serum/plasma samples. However, different limitations hinder their use in some cases. Mass spectrometry (MS)-based proteomics analysis has recently appeared as a promising option to assess panels of protein bioma...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD019403 | Pride
Human Microfluidic device Plasma Centrifugation Dda 
ProteomicsIdentification of candidate interactors of Bacillus subtilis rhomboid protease YqgP
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity needs to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtil...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014566 | Pride
Transporter Intramembrane protease Co-immunoprecipitation Lipid membrane Rhomboid protease Proteostasis Lc-ms/ms 
ProteomicsCharacterization of Spp1-TAP and Mer2-TAP interactomes
Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic recombination is initiated by programmed double strand break (DSB) formation that in budding yeast is directed in gene promoters by histone H3K4 di/trimethylation. T...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-01-30 | PXD007590 | Pride
Spp1 Interactomics Saccharomyces cerevisiae Meiosis Mer2 
ProteomicsInteractome of Toxoplasma gondii Pre-mRNA 3’ Processing Complexes
A proper 3’end processing of mRNAs is regarded as one of the regulatory cornerstones of gene expression. In a parasite that must answer to the high regulatory requirements of its multi-host life style, the need is grand for adopting additional means to partition the distinct transcriptional signatur...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2021-07-16 | PXD024326 | Pride
Pre-mrna processing Toxoplasma gondii 3'utr Interactomics Nanolc-ms/ms 
ProteomicsEffect of rRNA methylation defect on protein composition of human ribosomes
Ribosomal RNAs (rRNAs) are main effectors of mRNA decoding, peptide-bond formation and ribosome dynamics during translation. Ribose 2'-O-methylation is the most abundant rRNA chemical modification, and display a complex pattern in rRNA. We globally challenged rRNA 2'-O-Me by inhibiting the rRNA meth...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007244 | Pride
Ribosomes Fibrillarin Nanolc-ms/ms 
ProteomicsProteomic analysis of virion and genomic fibre of Mimivirus reunion
Mimivirus is the prototype of the Mimiviridae family of giant dsDNA viruses, initially isolated in Acanthamoeba. Little is known about the organization of the viral genome inside the membrane limited nucleoid and whether unpacking or other rearrangements are required prior to early transcription and...
ORGANISM(S): Acanthamoeba castellanii mimivirus 
2022-07-29 | PXD021585 | Pride
Mimivirus reunion Virion Nanolc-ms/ms Genomic fibre 
Proteomicsp140Cap interactome in breast cancer cells
Even though neuronal and cancer cells have quite different purposes in the body, there is growing evidence that metastatic cancer cells implement signaling mechanisms found in homeostasis of synaptic growth/plasticity. Recent studies have highlight some remarkable similarities in both form and funct...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-25 | PXD008778 | Pride
Breast cancer Co-ip Nanolc-ms/ms P140cap 
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