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ProteomicsProteomic Analysis of Canine Extracellular Matrix in Mammary Tumor Progression
Canine mammary gland tumors are common and bear striking similarities to human breast cancer, making them a valuable model for comparative oncology. This study examined changes in the extracellular matrix (ECM) associated with tumor progression in spontaneous canine mammary carcinomas, aiming to ide...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2026-04-13 | PXD074203 | Pride
Proteomics Canine mammary tumor Extracellular matrix Lc-ms/ms 
ProteomicsEstablishment and characterization of a tumoroid biobank derived from dog patients’ mammary tumors for translational research
Breast cancer is the most frequent cancer among women causing the greatest number of cancer-related deaths. Cancer heterogeneity is a main obstacle to therapies. Around 96% of the drugs fail from discovery to the clinical trial phase probably because of the current unreliable preclinical models. New...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2023-03-11 | PXD031440 | Pride
Dog patients Drug screening Breast cancer Tumoroid Biobank 
ProteomicsCORRELATION OF CANINE BONE MARROW DERIVED MESENCHYMAL STEM CELLS GENOMICS WITH SECRETOME PROTEOMIC COMPOSITION
The adult stem cells have become prominent candidates for the treatment of various diseases in veterinary practice. Therefore, the main goal of our study was to provide a complex study of canine bone marrow derived mesenchymal stem cells (BMMSCs) and conditioned media, isolated from healthy adult do...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) 
2019-07-15 | PXD013058 | Pride
Lc-msms Stem-cell Proteomic Secretome Canine 
ProteomicsReal-time molecular diagnosis of tumors using water-assisted laser desorption/ionization mass spectrometry technology
This dataset contains MS imaging raw data as well as the SCiLS file used to confirm the regions in dog sarcoma biopsies classified by the SpiderMass system after analysis of the consecutive tissue section. All the tissues were gathered during dog sarcoma surgeries, snap-frozen and analysed later in ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2019-04-12 | PXD010990 | Pride
Molecular signatures Sarcoma Real-time Cancer Non-invasive Diagnostic Laser microprobe Spidermass Surgery Ambient ionization mass spectrometry 
ProteomicsOn-tissue spatially-resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape
Here we present an approach to identify N-linked glycoproteins and deduce their spatial localization using a combination of MALDI N-glycan MSI and spatially-resolved glycoproteomics. We subjected glioma biopsies to on-tissue PNGaseF digestion and MALDI-MSI and found that the glycan HexNAc4-Hex5-NeuA...
ORGANISM(S): Canis lupus 
2023-03-11 | PXD025826 | Pride
Glioblastoma Spatially-resolved Glycoproteomics Haptoglobin Sialic-acid Maldi-msi Hypersialylation Glycan-imaging 
UnknownEndocrine control of canine mammary neoplasms: serum reproductive hormone levels and tissue expression of steroid hormone, prolactin and growth hormone receptors.
Not available
S-EPMC4570623 | biostudies-literature
UnknownVector-borne diseases.
Not available
S-EPMC7009857 | biostudies-literature
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