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TranscriptomicsTranscription profiling by array of human MCF cells treated with estrogen
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in b...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-11324 | biostudies-arrayexpress
ProteomicsAnalysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
HER2 is a transmembrane receptor tyrosine kinase, which plays a key role in breast cancer due to a common genomic amplification. It is used as a marker to stratify patients in the clinic and is targeted by a number of drugs including Trastuzumab and Lapatinib. HER2 has previously been shown to trans...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD003915 | Pride
Breast cancer Rime Her2 
TranscriptomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-39623 | biostudies-arrayexpress
ProteomicsHNF4G and FOXA1 are context-specific drivers of pancreatic cancer progression
Despite recent advances in the treatment of pancreatic adenocarcinoma (PDAC), clinical outcome remains poor. Previous evidence linked the pioneer transcription factor FOXA1 as a mediator of new regulatory elements that drive tumour progression in models of late-stage disease. Given the critical role...
ORGANISM(S): Homo sapiens (Human) 
2025-08-13 | PXD045980 | Pride
Foxa1 Pancreatic adenocarcinoma Hnf4g Rime 
GenomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-40129 | biostudies-arrayexpress
ProteomicsTET2 is a component of the ER complex and controls 5mC to 5hmC conversion at ER cis-regulatory regions
Estrogen receptor-alpha (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. GATA3 is a transcription factor that has been closely linked to ER function, but the role of GATA3 in ER-transcriptional activity is not clear. We sought to identify the contribution of GATA3 to...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD019438 | Pride
Breast cancer Estrogen receptor alpha Tet2 Qplex-rime 
ProteomicsA quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes
Understanding the dynamics of endogenous protein-protein interactions in complex networks is pivotal in deciphering the mechanisms underlying diseases such as cancer. To enable the in-depth analysis of protein interactions in chromatin-associated protein complexes, we have previously developed a met...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD007968 | Pride
Breast cancer Proteomics Qplex-rime Tmt 4-hydrotamoxifen Rime Clinical samples Isobaric labelling Patient derived xenografts (pdx) Estrogen receptor alpha Interactome 
ProteomicsFOXA1 directs H3K4 monomethylation at enhancers via recruitment of the methyltransferase MLL3
FOXA1 is a pioneer factor that is important in hormone dependent cancer cells to stabilise nuclear receptors, such as estrogen receptor (ER) to chromatin. FOXA1 binds to enhancers regions that are enriched in H3K4mono- and dimethylation (H3K4me1, H3K4me2) histone marks and evidence suggests that the...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD005253 | Pride
Foxa1 H3k4 Mll3 Human Lcmsms 
ProteomicsER/PR RIME Experiments in MCF7 and T47D cell lines
Immuno-precipitation followed by MS was performed using the RIME protocol in this study. Estrogen Receptor (ER) and Progestorone Receptor (PR) were targetted using antibodies. The experiments were performed in a quantitative manner using SILAC labelling. Cells grown in complete serum (estrogenic) co...
ORGANISM(S): Homo sapiens (Human) 
2015-05-26 | PXD002104 | Pride
Pr Rime Estrogen receptor Progesterone receptor Er 
ProteomicsARID1A RIME in human cell lines and tissue xenografts.
Examination of chromatin-bound proteins associated with ARID1A, BRG1 and ERa in MCF7 cells and ERa in ER+ patient-derived xenografts using RIME protocol and mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2019-10-31 | PXD011810 | Pride
Human Arid1a Rime Qplex 
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