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ProteomicsTMT-based quantitative proteomics analysis reveals the attenuated replication mechanism of Newcastle disease virus caused by nuclear localization signal mutation in viral matrix protein
Nuclear localization of cytoplasmic RNA virus proteins mediated by intrinsic nuclear localization signal (NLS) plays essential roles in successful virus replication. We previously reported that NLS mutation in the matrix (M) protein obviously attenuates the replication and pathogenicity of Newcastle...
ORGANISM(S): Cricetidae 
2020-05-22 | PXD018098 | Pride
Newcastle disease virus  matrix protein  nuclear localization signal  nucleocytoplasmic trafficking  tmt  quantitative proteomics 
TranscriptomicsGenomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL), a rapidly progressing malignancy mostly arising in HIV-infected patients. Even under conventional chemotherapy, PEL continues to portend nearly 100% mortality within several months, which ur...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65418 | biostudies-arrayexpress
ProteomicsHuman proteomics analysis of BRD4 targeted small-molecules in KSHV+ cells by Orbitrap Eclipse and MaxQuant
In this project, we used proteomics to identify and compare protein profile changed in SIM-1, MZ-1, or JQ-1 treated TIVE-LTC, a KSHV long-term infected immortalized endothelial cell line.
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075129 | Pride
Brd4 Sim-1 Kshv Mz-1 Jq-1 
ProteomicsHuman cancer cell MCF-7 IP-PTEN MS
The MCF-7 cells were lysed using RIPA lysis buffer with a high salinity content to break out non-covalent binding of proteins. Then IP under partially denaturing conditions was performed and demonstrated that anti-PTEN precipitates were detected as smear bands, then mass spectrometry analysis of the...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD021544 | Pride
Human Breast cancer Pten Ms 
UnknownIsolation and characterization of two homolog phages infecting Pseudomonas aeruginosa.
Not available
S-EPMC9348578 | biostudies-literature
ProteomicsMCF-7 PTEN-Nedd8 IP-MS
We intended to elucidate the underlying mechanism of PTEN-Nedd8 in tumorigenesis. So, we firstly employed affinity purification and mass spectrometry to interrogate PTEN-Nedd8 interactome in nucleus.
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD011395 | Pride
Human Breast cancer cell Nedd8 Pten Ip-ms 
ProteomicsMCF-7 Flag-need8 IP-MS
To allow the proteomic identification of proteins modified with Nedd8, we firstly employed affinity purification and mass spectrometry to interrogate Nedd8 interactome.
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD011368 | Pride
Human Breast cancer cell Ip-ms Mcf-7 
UnknownApatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia.
Not available
S-EPMC5831852 | biostudies-literature
ProteomicsProteomic analysis of PDCoV-infected HIEC-6 cells
Data-independent acquisition (DIA) is a new type of mass spectrometry data acquisition developed in recent years. The entire scanning range of mass spectrometry can be divided into several windows based on the mass-to-charge ratio (m/z), and then all the parent ions in each window are fragmented and...
ORGANISM(S): Homo Sapiens 
2024-02-20 | PXD049713 |
TranscriptomicsRegulation of Gene Expression by Connective Tissue Growth Factor (CTGF) in Mesenchymal Stromal Cells (MSCs)
mRNA from bone marrow-derived MSCs stably expressing CTGF-specific shRNA (or empty vector control) was analyzed for differential gene expression. Significant differences were found in cell proliferation-related genes, especially genes related to the M phase of the cell cycle, which were down-regulat...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-47575 | biostudies-arrayexpress
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