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ProteomicsExpression dynamics in mammalian cells responding to protein misfolding stress
The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth analysis of a cervical cancer cell line responding to protein misfolding stress induced by dithiothreitol treatment, quantifying the dynamics of mRNA and p...
ORGANISM(S): Homo sapiens (Human) 
2016-03-14 | PXD002039 | Pride
Human Lc-msms Protein misfolding stress Hela 
ProteomicsMammalian proteome changes during oxidative stress and stress of the endoplasmic reticulum
Stress due to protein misfolding in the endoplasmic reticulum affects transcription and translation, RNA and protein degradation. By integrating several large-scale datasets, we quantified transcription, translation, RNA-protein binding events, and protein levels for several thousands of genes in He...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD008575 | Pride
Er stress Translation Proteomics Oxidative stress 
MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
TranscriptomicsThe specifcity of innate immune response is enforced by repression of interferon-response elements by NFkB p50
The specific binding of transcription factors to cognate sequence elements is thought to be critical for the generation of specific gene expression programs. The transcription factors nuclear factor kB (NF-kB) and the interferon (IFN) regulatory factors (IRFs) bind to the kB site and the interferon ...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-27112 | biostudies-arrayexpress
UnknownRole of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation.
Not available
S-EPMC3790283 | biostudies-literature
ProteomicsComparative phyloproteomics identifies conserved plasmodesmal proteins
Plasmodesmata are cytosolic bridges, lined by the plasma membrane and traversed by endoplasmic reticulum, connecting cells and tissues, and critical for many aspects of plant biology. While plasmodesmata are notoriously difficult to extract, tissue fractionation and proteomic analyses can yield valu...
ORGANISM(S): Physcomitrella patens subsp. patens (Moss) Arabidopsis thaliana (Mouse-ear cress) 
2023-01-13 | PXD038964 | Pride
Arabidopsis Plasmodesmata Phyloproteomics Physcomitrium 
ProteomicsComprehensive protein interactome analysis of a key RNA helicase: the detection of novel stress granule proteins
We conducted an unbiased large-scale study to map the protein-protein interactome of DDX6 using immunoprecipitation and mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2015-07-27 | PXD002070 | Pride
Ddx6 Stress granules Mass spectrometry P bodies Splicing Rna Sumoylation Gw bodies Sumo Decapping Gran1 Mrna decay Gran2 Helicase Nufip2 Post-transcriptional regulation Fam195b Processing bodies Fam195a Translation regulation 
TranscriptomicsRegulation of HB-EGF by miR-212 and acquired cetuximab-resistance in head and neck cancer
To determine the mechanism of cetuximab-resistance in head and neck cancer, a cetuximab-sensitive cell line (SCC1) and its cetuximab-resistant derivative (1Cc8) were analyzed for differentially expressed genes using DNA microarrays. 900 differentially expressed genes were found using the statistical...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-21483 | biostudies-arrayexpress
no omics definedChromatin immunoprecipitation of human breast cancer cell line MCF-7 treated with 17beta-estradiol
ChIP-DSL experiments using ER alpha antibody on v1 20k promoter array
ORGANISM(S): Homo sapiens 
2007-03-31 | E-MEXP-984 | biostudies-arrayexpress
GenomicsGenome-wide maps of epigenetic features in G1E model and in mouse primary erythroblasts.
Interplays among lineage specific nuclear proteins, chromatin modifying enzymes and the basal transcription machinery govern cellular differentiation, but their dynamics of actions and coordination with transcriptional control are not fully understood. Alterations in chromatin structure appear to es...
ORGANISM(S): Mus musculus 
2011-07-05 | E-GEOD-30142 | biostudies-arrayexpress
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