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ProteomicsEffect of transplantation on human islets
To assess the effect of transplantation on human islet signature, we transplanted 500-800 human iselts under the kidney capsule of diabetic mice. The mice were rendered diabetic with allowan. The transplanted islets were collected after 30 days, and compared to non-trasnplanted islets.
ORGANISM(S): Homo sapiens (Human) 
2025-04-03 | PXD044502 | Pride
Transplant Human islets 
ProteomicsIn vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
Objective: The loss of insulin-secreting β-cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into diabetic patients. However, the effects of hyperglycemia environment on the t...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD015071 | Pride
Human induced pluripotent stem cells Hyperglycemia Oxidative stress Lc-ms/ms 
ProteomicsChronically elevated exogenous glucose elicits antipodal effects on the proteome signature of differentiating human pancreatic progenitors
The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms governing these processes is thus extremely valuable for managing the disease progr...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022177 | Pride
Human Ipscs Glucose 
Proteomicsin vivo environment swiftly restricts human pancreatic progenitors towards monohormonal identity via a HNF1A/HNF4A mechanism
Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy aimed at improving or curing certain forms of diabetes. Nevertheless, despite important recent advances, the efficient production of functionally mature β-cells is yet to be achieve...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD015955 | Pride
Human Ipsc Alginate In vivo transplant 
ProteomicsVariation in proteome landscape in human pancreatic islets
Human pancreatic islets were collected from cadavic donors. Left our islets from 16 donors not used for transpantation were lysed and whole protein extract were collected. 16 samples were used to be able to assess variations in the proteome landscape between donors.
ORGANISM(S): Homo sapiens (Human) 
2025-04-03 | PXD041619 | Pride
Human Pancreas Islets 
ProteomicsEDC exposure during SC-islet differentiation
We aimed to asses how EDC exposure in combination with a genetic predisposition for diabetes could impact pancreatic endocrine cell development. For this, we used a protocol to generate Stem-cell islets (SC-islets) from induced pluripotent stem cells (iPSCs) following a 7 satege protocol. For 2 week...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD065436 | Pride
Sc-islets Ipscs Edc 
ProteomicsAlginate encapsulation of differentiating hiPSCs
Here we characterize the impact of cell confinement on the pancreatic islet signature during the guided differentiation of alginate encapsulated human induced pluripotent stem cells.
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD012704 | Pride
Human Lc-ms3 
ProteomicsInitial effects of BBN treatment on mouse bladder
Characterizing the initial stages of oncogenic transformation in bladder cancer. Littermate male mice were transferred in single-use plastic cages in order to be treated with the BBN carcinogen. The treatment dose used in this work was 0.05% BBN delivered in drinking water for up to 12 days. Bladde...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-12 | PXD054745 | Pride
Bbn Mouse Bladder 
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