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MetabolomicsSeipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights
ProteomicsPhosphoproteome dynamics at the transition from meiosis I to meiosis II
The proteome and phosphoproteome in meiosis from metaphase I to metaphase II after synchronisation using the GALpromoter-NDT80 block-release system are presented. The phosphoproteome dynamics are presented in two contexts: 1- in a wild-type context with 10 time points at 10min intervals 2- in a Cdc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-16 | PXD043862 | Pride
Meiosis Phosphoproteome Cdk 
ProteomicsIncrease in harmful R-loops associates with different alterations in mRNP composition
Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insights into the cellular mechanisms that prevent genome instability. Here, we identify three RNA-binding proteins, Rie1, Rim4 and She2, whose stoichiometry is importa...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2025-06-13 | PXD057248 | Pride
R-loops Tho complex Rna-binding proteins Messenger ribonucleoparticle 
ProteomicsThe diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction
Orthohantaviruses are rodent-borne emerging viruses known to cause severe diseases in humans but no apparent pathology in their small mammal reservoirs. However, the mechanisms leading to tolerance or pathogenicity in humans and persistence in rodent reservoirs are poorly understood, as is the manne...
ORGANISM(S): Homo sapiens (Human) 
2022-10-04 | PXD032365 | Pride
Human Orthohantavirus Restriction Rodent Infection 
ProteomicsThe ternary complex CEP90, FOPNL and OFD1 specifies the future location of centriolar distal appendages, and promotes their assembly
Cilia assembly starts with centriole to basal body maturation, migration to the cell surface and docking to the plasma membrane. The basal body docking process involves the interaction of both the distal end of the basal body and the transition fibers (or mature distal appendages), with the plasma m...
ORGANISM(S): Homo sapiens (Human) 
2022-07-20 | PXD028740 | Pride
Pibf1 Kiaa0753 Centriolar Ofd1 Ofip For20 Cep90 Mnr Centrosomal Fopnl 
ProteomicsA histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium
To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs, 20-30 nucleotides in length, bind to PIWI proteins and guide them to nascent transcripts by sequence complementarity, triggering the recruitm...
ORGANISM(S): Paramecium tetraurelia 
2025-09-22 | PXD063336 | Pride
Histone methyltransferase Programmed dna elimination Prc2 Small rna Paramecium 
ProteomicsA genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition
The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This strategy is tightly regulated by the glucose repression pathway, which prevents the expression of genes required for the utilization of alternative carbon sour...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-10-03 | PXD068555 | Pride
Glucose signaling Yeast 2-deoxyglucose Ampk Pp1 
ProteomicsRanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes called annulate lamellae (AL). Though discovered in the mid-20th century, AL’s function and biogenesis re...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD073946 | Pride
Nuclear expansion Climp63 (ckap4) G1 Single molecule localization microscopy (smlm) Annulate lamellae Nuclear growth Fg repeats Ranbp2 (nup358) Nuclear pore complex Cytoplasmic nucleoporin foci 
ProteomicsA H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
BackgroundThe ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1), whose recruitment is H3K27me3-dependent. Yet it is unclear how H3K27me3 contri...
ORGANISM(S): Paramecium tetraurelia 
2026-03-03 | PXD065449 | Pride
ProteomicsThe ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina
BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia. Its role in the retina remains poorly understood. This study provides a comprehensive...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD060682 | Pride
Bri23 Retina Retinal dystrophy Protein interactions Itm2b 
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