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ProteomicsFOXL2 interaction with different binding partners regulates the dynamics of granulosa cell differentiation across ovarian development
FOXL2 is a transcription factor essential for female fertility, expressed in somatic cells of the ovary, notably granulosa cells. In the mouse, Foxl2 deletion leads to partial sex reversal postnatally. However, deletion of the gene in 8-week-old females leads to granulosa to Sertoli cell transdiffer...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-25 | PXD043951 | Pride
Ovary Chip-sicap Foxl2 
ProteomicsChromatin-bound proteins co-localized with CTCF during mES cell neuronal differentiation
Using Chromatin immunoprecipitation combined with Selective Isolation of Chromatin Associated Proteins (ChIP-SICAP), we define the chromatin-bound proteins co-localized with CTCF in mouse embryonic stem cells (ES) and neuronal stem (NS) cells. We uncover the proteins that are differentially co-local...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-13 | PXD048470 | Pride
Chip-sicap Ctcf Rna-binding proteins Chromatin 
ProteomicsSingle-minded homolog 2 resides in the chromatin protein network of androgen receptor and modulates gene expression in prostate cancer cells Single-minded homolog 2 resides in the chromatin protein network of androgen receptor and modulates gene expression in prostate cancer cells
We investigated the composition of chromatin protein network around endogenous androgen receptor (AR) in VCaP castration resistant prostate cancer cells using recently developed chromatin-directed proteomic approach called ChIP-SICAP . The androgen-induced AR chromatin protein network contained exp...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD025193 | Pride
Smarca4 Sim2 Castration-resistant prostate cancer cell Chip-sicap Chromatin accessibility Gene expression Protein-protein interactions Chromatin Androgen signaling Chromatin-mediated interaction 
ProteomicsStudying the core circuitry of pluripotency by selective isolation of chromatin-associated proteins
Here we have developed a method to identify chromatin-bound partners of a protein of interest by selective isolation of chromatin-associated proteins (SICAP) followed by mass spectrometry. We applied SICAP to identify chromatin-binding proteins associated to Oct4, Sox2 and Nanog in mouse embryonic s...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-19 | PXD003798 | Pride
Mass spectrometry Mouse embryonic stem cell Chromatin Sicap 
ProteomicsIdentification of CEBPA and RUNX1 interactors in 3q-rearranged AML (MOLM-1)
Chromatin immunoprecipitation with specific isolation of chromatin associated proteins (ChIP-SICAP) was used to identify chromatin-bound interactors of CEBPA and RUNX1 in the 3q-rearranged human myeloid leukemia cell line MOLM-1.
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD020050 | Pride
Runx1 Acute myeloid leukemia Chip-sicap Cebpa Human 
ProteomicsIdentification of CEBPA and RUNX1 interactors in 3q-rearranged AML
Chromatin immunoprecipitation with specific isolation of chromatin associated proteins (ChIP-SICAP) was used to identify chromatin-bound interactors of CEBPA and RUNX1 in the 3q-rearranged human myeloid leukemia cell line MUTZ-3.
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD020045 | Pride
Runx1 Acute myeloid leukemia Chip-sicap Cebpa Human 
ProteomicsIdentification of CEBPA and RUNX1 interactors in 3q-rearranged AML (HNT-34)
Chromatin immunoprecipitation with specific isolation of chromatin associated proteins (ChIP-SICAP) was used to identify chromatin-bound interactors of CEBPA and RUNX1 in the 3q-rearranged human myeloid leukemia cell line HNT-34.
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD020054 | Pride
Runx1 Acute myeloid leukemia Chip-sicap Cebpa Human 
ProteomicsProtease-resistant streptavidin for interaction proteomics
Streptavidin-mediated enrichment is a powerful strategy to identify biotinylated biomolecules and their interaction partners by mass spectrometry. Since contamination by streptavidin limits protein identification, we here present protease-resistant streptavidin beads (prS). Their application to diff...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-04-08 | PXD015858 | Pride
Lipid Mass spectrometry Interactors Streptavidin Membrane proteins Chip-sicap Biotinylation Bioid Chip Ceramide-binding proteins 
ProteomicsProtease-resistant streptavidin for interaction proteomics
Streptavidin-mediated enrichment is a powerful strategy to identify biotinylated biomolecules and their interaction partners by mass spectrometry. Since contamination by streptavidin limits protein identification, we here present protease-resistant streptavidin beads (prS). Their application to diff...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-05-27 | PXD016576 | Pride
Streptavidin Affinity purification Mass spectrometry Dna pull down Chip sicap Lipid binding protein Bioid Membrane protein Chip Biotin 
ProteomicsGenomic rewiring of Sox2 chromatin interaction network during differentiation of ESCs to postmitotic neurons
Cellular differentiation requires cells to undergo dramatic but strictly controlled changes in chromatin organization, transcriptional regulation, and protein production and interaction. To understand the regulatory connections between these processes, we applied a multi-omics approach integrating p...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-04 | PXD016080 | Pride
Differentiation Lc-msms Mouse Neurons Escs 
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