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ProteomicsTime-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators; however, their acetylation targets, site-specific acetylation kinetics, and function in proteome regulation are incompletely understood. We combined quantitative proteomics with novel CBP/p300-specific catalytic i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000095981 | MassIVE
ProteomicsHs_PhosoProteomicScreen
Hs_PhosoProteomicScreen
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe001952 | PeptideAtlas
ProteomicsConvergence of Ubiquitylation and Phosphorylation Signaling in Rapamycin-Treated Yeast Cells
Protein, Ubiquitylation, and Phosphorylation changes were quantified after 1 and 3 hours of rapamycin treatment in budding yeast. Approximately 3,600 proteins, 9,000 phosphorylation sites, and 2,500 ubiquitylation sites were quantified.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-10-03 | PXD000554 | Pride
Proteome Tor Ubiquitylation Rapamycin Phosphorylation 
ProteomicsSystems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation
In this study, we have analyzed BCR induced dynamic composition of the BCR signalosome and global changes in BCR induced phosphoproteome and ubiquitylation events using high resolution LC-MS/MS
ORGANISM(S): Mus musculus (Mouse) 
2015-06-02 | PXD001440 | Pride
B-cells Bcr signaling A20 b cell line 
ProteomicsProteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
Post-translational modification of proteins by lysine acetylation plays important regulatory roles in living cells. The budding yeast Saccharomyces cerevisiae is a widely used unicellular eukaryotic model organism in biomedical research. S. cerevisiae contains several evolutionary conserved lysine a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-06-02 | PXD002287 | Pride
Acetylation Acetylome Yeast Rpd3 Saccharomyces cerevisiae 
ProteomicsUnraveling Lysine Deacetylase Inhibitor Specificities for Endogenous Acetylation Sites
Lysine deacetylases (KDACs) are important regulators of biological processes. KDAC inhibitors (KDACIs) are important tools for basic research and attractive therapeutic candidates, yet their effects on in-vivo acetylation sites are poorly known. Here we obtained acetylation signatures for 19 differe...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-02-16 | PXD001377 | Pride
Proteomics Bufexamac Mass spectrometry Silac Nicotinamide Hdac Acetylation Tenovin-6 Kdac Sirtuin Deacetylase inhibitor 
ProteomicsDNA repair proximity landscape analysis reveals shieldin as a key regulator of NHEJ-dependent processes
By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interaction neighborhood maps of the endogenously expressed DNA repair factors 53BP1, BRCA1, and MDC1.
ORGANISM(S): Homo sapiens (Human) 
2018-04-13 | PXD009284 | Pride
Dna damage repair Shieldin Proximity labeling 
ProteomicsTime-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators; however, their acetylation targets, site-specific acetylation kinetics, and function in proteome regulation are incompletely understood. We combined quantitative proteomics with novel CBP/p300-specific catalytic i...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-06-10 | PXD005252 | Pride
Cbp Acetyltransferase Acetylation P300 
ProteomicsLysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2015-06-02 | PXD002277 | Pride
Yeast Human Liver Bacteria Mouse Succinylation Acetylation 
OtherConvergence of ubiquitylation and phosphorylation signaling in rapamycin-treated yeast cells.
Data from ProteomeXchange, PXD ID: PXD000554. Experiment: SILAC_SC_Rap048_2ndrep_SCX, file: folder summary. Published as part of Mol Cell Proteomics. 2014 Aug;13(8):1979-92 . From the Abstract: {{i}} ... Here, we used a mass-spectrometry-based proteomics approach for the parallel quantification of ...
ORGANISM(S): Yeast 
GPM32320003896 | GPMDB
Resource Reanalysis 
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