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ProteomicsA Modular Chromosomal Passenger Complex Rewires Chromosome Segregation in Plasmodium berghei
Faithful chromosome segregation relies on precise kinetochore-microtubule interactions and checkpoint surveillance, yet the molecular basis of these processes varies widely across eukaryotes and is only beginning to be defined in apicomplexan parasites. In the malaria parasite Plasmodium berghei, ch...
ORGANISM(S): Plasmodium berghei ANKA 
2026-06-01 | PXD068832 | Pride
Malaria Evolutionary cell biology Apicomplexa Kinetochore Aurora kinase Chromosomal passenger complex Plasmodium 
ProteomicsPlasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. During schizogony, asynchronous nuclear replication produces a...
ORGANISM(S): Plasmodium berghei ANKA 
2026-01-13 | PXD068821 | Pride
Male gametogony Plasmodium Aurora kinase Cytokinesis Warwick_rtp Spindle Chromosomal passenger complex (cpc) Incenp Karyokinesis Mtoc Transmission 
ProteomicsPhospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin.
Global regulation of spindle-associated proteins is crucial in oocytes due to the absence of centrosomes and their very large cytoplasmic volume, but little is known about how this is achieved beyond involvement of the Ran-importin pathway. We previously uncovered a novel regulatory mechanism in Dr...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-04 | PXD030445 | Pride
Borealin. Oocytes Drosophila Microtubule-associated proteins 14-3-3 Quantitative proteomics Chromosomal passenger complex 
ProteomicsDirect Nucleosome Binding of Borealin Secures Chromosome Association of the Chromosomal Passenger Complex
CPC-NCP complexes were crosslinked using EDC and analysed by mass spectrometry. The results showed Borealin is critical for nucleosome binding made extensive contacts with NCPs, whereas Survivin interactions are mostly limited to the BIR domain and the H3 N-terminal tail as expected. Mapping the cro...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2019-09-30 | PXD012882 | Pride
Nucleosome core particles Chromosomal passenger complex Crosslinking 
ProteomicsMKLP2 walks along microtubules and takes the CPC along for a ride
The mitotic kinesin-like Protein 2 (MKLP2, KIF20A) is essential for the proper execution of cytokinesis and required to ‘passage’ the chromosomal passenger complex (CPC) from the chromosomes in (pro)metaphase to the spindle midzone and equatorial cortex in anaphase. Together with MKLP1 (KIF23) and M...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD014665 | Pride
Mklp2 Motor proteins Chromosomal passenger complex 
UnknownSurvivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.
Not available
S-EPMC1369225 | biostudies-literature
ProteomicsMass spectrometry analysis of chromosomal passenger complex proteins and kinetochore proteins in Trypanosoma brucei
We performed chemical crosslinking mass spectrometry of native protein complexes purified from Trypanosoma brucei procyclic cells to obtain protein-protein interaction information for the chromosomal passenger complex (CPC) and kinetochore complex. Crosslinks among CPC subunits were detected using Y...
ORGANISM(S): Trypanosoma brucei 
2023-10-13 | PXD045987 | Pride
Kinetochore Crosslinking mass spectrometry 
UnknownSwitching of INCENP paralogs controls transitions in mitotic chromosomal passenger complex functions.
Not available
S-EPMC6681789 | biostudies-literature
UnknownThe mechanoresponsive chromosomal passenger complex sustains furrow ingression under confinement.
Not available
S-EPMC12723229 | biostudies-literature
UnknownBorealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex.
Not available
S-EPMC6891087 | biostudies-literature
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