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ProteomicsSpatial omics of acute myocardial infarction reveals a novel mode of immune cell infiltration
Myocardial infarction (MI) continues to be a leading cause of death worldwide. Even though it is well-established that the complex interplay between different cell types determines the overall healing response after MI, the precise changes in the tissue architecture are still poorly understood. Here...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-16 | PXD066993 | Pride
Human Infarction Spatial proteomics Lc-ms Heart Myocardial 
ProteomicsSpatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets
High-grade serous ovarian cancer (HGSOC) is often detected at an advanced stage, where curative treatment options are limited. Recent advances in ultrasensitive mass spectrometry-based spatial proteomics have provided a unique opportunity to uncover molecular drivers of early tumorigenesis and novel...
ORGANISM(S): Homo sapiens (Human) 
2025-10-19 | PXD069630 | Pride
Stic Fallopian tube Ovarian cancer 
ProteomicsDeep visual proteomics uncovers nociceptor diversity and pain targets
The richness of our somatosensory experience is reflected in the functional diversity of somatic sensory neurons. Single-cell sequencing (scRNA) of sensory neurons has revealed a molecular basis for such diversity1–3. However, sensory neuron diversity has yet to be captured at the level of the prote...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-10 | PXD070495 | Pride
ProteomicsK27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation
Conjugation of ubiquitin (Ub) to numerous substrate proteins regulates virtually all cellular processes. Eight distinct ubiquitin polymer linkages specifying different functional outcomes are generated in cells. However, the roles of some atypical poly-ubiquitin topologies, in particular linkages vi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD023579 | Pride
Ubiquitin Proteomics K27 
ProteomicsA streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis
Formalin fixation and paraffin-embedding (FFPE) is the most common method to preserve human tissue for clinical diagnosis and FFPE archives represent an invaluable resource for biomedical research. Proteins in FFPE material are stable over decades but their efficient extraction and streamlined analy...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD017269 | Pride
Biobank Ffpe Cancer Proteomics Tissue Mass spectrometry Protocol 
ProteomicsEfficient checkpoint signaling depends on the integrated activities of Bub1 and the RZZ complex
Kinetochore localized Mad1 is essential for generating a “wait anaphase” signal during mitosis hereby ensuring accurate chromosome segregation. Inconsistent models for the function and quantitative contribution of the two mammalian Mad1 kinetochore receptors: Bub1 and the Rod-Zwilch-ZW10 (RZZ) compl...
ORGANISM(S): Homo sapiens (Human) 
2019-02-19 | PXD012235 | Pride
Mitosis proteomics bub1 
ProteomicsGain-of-function mutations amplify cytotoxic FAM111 protease activity in poikiloderma, gracile bone dysplasia and Kenny-Caffey syndromes
Dominant missense mutations in the human serine protease FAM111A underlie perinatally lethal gracile bone dysplasia and Kenny-Caffey syndrome 1-3, yet how FAM111A mutations lead to disease is not known. We show that FAM111A proteolytic activity suppresses DNA replication and transcription by displac...
ORGANISM(S): Homo sapiens (Human) 
2020-08-10 | PXD017978 | Pride
Kenny-caffey syndromes Fam111 Genetic disorder Poikiloderma Proteases Replication stress Transcrition 
ProteomicsThe TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition
It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a premature entry into G2 from early S-phase independently of ATR/CHK1 kinases. TRESLIN-MTBP acts transiently ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035353 | Pride
Atr Dna replication Cell cycle 
ProteomicsSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically charact...
ORGANISM(S): Homo sapiens (Human) 
2020-11-18 | PXD019909 | Pride
Protein expression T cell Skin Mass spectrometry Endothelial cells Macrophages Stratum corneum Interleukins Collagen Dermis Proteomics Melanocytes Mast cell Keratin Subcutis 
ProteomicsDeep Visual Proteomics defines single-cell identity and heterogeneity
Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial proteomics, a key challenge remains connecting images with single-cell-resolution protein abundance measurements. Here we introduce Deep Visual Proteomics (DVP), which combines artificial-intelligence-driven ima...
ORGANISM(S): Homo sapiens (Human) 
2022-04-27 | PXD023904 | Pride
Microscopy Digital pathology Proteomics Laser microdissection 
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