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ProteomicsProteomics approach unravels early changes in Human Fibro-blasts-Pancreatic Ductal Adenocarcinoma cells crosstalk
Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Non-specific symptoms, lack of biomarkers in the early stages, and drug resistance due to the presence of a dense fibrous stroma all contribute to poor outcome of this disease. The extracellular matrix of PDAC...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030974 | Pride
Cancer associated fibroblasts  pdac microenvironment  proteomics  ingenuity pathway analysis 
ProteomicsFood-associated Lactiplantibacillus plantarum C9O4 reverts inflammation and apoptosis in intestinal epithelial cells: a proteomic insight
Nowadays, Western diets and lifestyle lead to an increasing occurrence of chronic gut inflammation, that represents an emerging health concern with still a lack of successful therapies. Fermented foods, and their associated Lactic Acid Bacteria, have recently regained popularity for their probiotic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042175 | Pride
Lpb. plantarum c9o4 Inflammation pathway Proteomics Intestinal cells 
ProteomicsProteomics investigation of Nucleostemin role in Nucleo-phosmin mutated OCI-AML 3 cell line
Nucleostemin (NS; product of the GNL3 gene) is a nucleolar/nucleoplasm shuttling GTPase whose levels are high in stem cells while rapidly decreasing upon differentiation. NS levels are also high in several solid and hematological neoplasms, including acute myeloid leukemia (AML). While a role in tel...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034012 | Pride
Nucleophosmin Nucleostemin Shotgun proteomics Acute myeloid leukemia 
ProteomicsEpigenetic Impairment of tumor potential of AML-derived extracellular vesicles
The biological active cargo of leukemia-derived extracellular vesicles (EVs) favours a wide variety of cancer-supportive mechanisms, including aberrant proliferative signalling, immune escape and drug resistance. However, whether and in which extent anti-neoplastic drugs affect EV cargo sorting is ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042168 | Pride
Vesicle Leukemia Tumorigenicity Epigenetic Saha 
ProteomicsSemaphorin 5A modulates focal adhesion pathway and lamellipodia formation in melanoma
Introduction Metastatic potential and rising incidence make cutaneous melanoma a major health concern worldwide. Although the therapies currently in use have proven effective, their use is limited by side effects arising and development of drug resistance. For this reason, re...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD065661 | Pride
Semaphorin 5a Melanoma Lamellipodia Focal adhesion 
ProteomicsProteomic analysis of Marinesco-Sjogren syndrome fibroblasts indicates pro-survival metabolic adaptation to SIL1 loss
Marinesco-Sjogren syndrome (MSS) is a rare multisystem pediatric disorder, caused by loss of function of the endoplasmic reticulum cochaperone SIL1 in about 60% of the patients. SIL1 acts as a nucleotide exchange factor for BiP, which plays a central role in secretory protein folding. SIL1-deficient...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD029086 | Pride
Autophagosome Protein folding Bip Pathway analysis Fibroblast Unfolded protein response Neurodegenerative disease 
ProteomicsTear proteomics reveals the molecular basis of the efficacy of human recombinant nerve growth factor treatment for Neurotrophic Keratopathy
Neurotrophic Keratopathy (NK),classified as an orphan disease (ORPHA137596), is a rare degenerative corneal disease characterized by epithelial instability and decreased corneal sensitivity caused by the damage to the corneal nerves. The administration of human recombinant nerve growth factor (rhNGF...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD025408 | Pride
Proteomics  tear  neurotrophic keratopathy  ngf  extracellular vesicles 
ProteomicsLoss of colonic primary cilia promotes inflammation and carcinogenesis
Primary cilia (PC) are important signaling hubs in cells and we explored their role in colorectal cancer (CRC) and colitis. In the colon we found PC to be mostly present on different subtypes of fibroblasts and exposure of mice to either chemically induced colitis-associated colon carcinogenesis (CA...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD033440 | Pride
Colon carcinogenesis Inflammation Primary cilia Colonic fibroblasts Colitis 
ProteomicsFACS-Proteomics strategy toward Extracellular Vesicles single-phenotype characterization in biological fluids: insights into the role of Leukocyte-derived EVs in Multiple Sclerosis
The isolation and proteomics characterization of Extracellular Vesicles (EVs) from body fluids represents a stimulating challenge to improve our knowledge of biology, considering the vast heterogeneity in terms of phenotype in vivo. Within a complex and dynamic scenario of EVs isolation and characte...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD049036 | Pride
Leukocyte-derived evs Multiple sclerosis Facs-proteomics Tears 
ProteomicsThe transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15R chain
Interleukin-15 (IL-15) is expressed in various cancers, including melanoma, where it exists in distinct membrane-associated isoforms. Primary melanoma cells predominantly express the non-cleavable transmembrane form (tmbIL-15), while metastatic cells also express a cleavable membrane-bound f...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD076097 | Pride
Il15 Cytokine Il15rα Skin cancer (melanoma) Natural killer (nk) cells 
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