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ProteomicsHuman endosomal proximity proteome
Here, using comparative proximity proteomics of critical retrieval sub-domain components Retromer and Retriever, their cargo adaptors, and a component of the opposing ESCRT-degradative sub-domain, we provide a data-rich resource that identifies new molecular details of retrieval sub-domain compositi...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD061918 | Pride
Hela Proximity proteomics Endosomes Tmt label Lc-ms/ms 
ProteomicsIdentification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
Commander is an endosome associated sixteen protein assembly that associates with the sorting nexin 17 (SNX17) cargo adaptor to regulate cell surface recycling of internalised integral membrane proteins including integrins and lipoprotein receptors. Mutations in Commander are causative for Ritscher-...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD067193 | Pride
Human Lrmda Retriever Tmt label Melanocyte Rab32 Lc-ms/ms 
ProteomicsSNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-ret...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010632 | Pride
Retromer flippase snx3 
ProteomicsMultiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling late-stage maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, manif...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041323 | Pride
Human Lysoip Neuroglioma Whole cell proteome H4 Retromer Secretome Cell surface proteome Lc-ms/ms 
ProteomicsIdentification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition
The endosomal-lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain cellular homeostasis. VPS29 is a central conductor of this network through its assembly into Retromer, Retriever and Commander endosomal sorting complexes...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD064959 | Pride
Commander Retriever Endosomes Lysosomes Retromer 
ProteomicsRetriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex which orchestrates cargo retrieval and recycl...
ORGANISM(S): Homo sapiens (Human) 
2018-01-15 | PXD007230 | Pride
Snx17 Retriever Retromer 
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
UnknownConvalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.
Not available
S-EPMC8121538 | biostudies-literature
UnknownCasirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8830904 | biostudies-literature
UnknownBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
Not available
S-EPMC9333998 | biostudies-literature
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