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ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - human CMTM6 interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070359 | Pride
Cd58 Cmtm6 
ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - mouse FAS interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070298 | Pride
Fas Cmtm6 Cd95 
ProteomicsCMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans - mouse CMTM3-8 interactome
The transmembrane protein CMTM6 promotes plasma membrane expression of immune checkpoint PD-L1, an important suppressor of anti-tumor immunity. Targeting of CMTM6 was proposed as a strategy to decrease surface PD-L1 and trigger cytotoxicity against tumors. In accord, ablation of CMTM6 in mouse cance...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD070246 | Pride
Cmtm3 Fas Cmtm8 Cmtm7 Cmtm6 Cmtm5 Cmtm4 Cd95 
ProteomicsAnalysis of GITR and OX40 signaling complexes
T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen receptors (TCR) and co-stimulatory or inhibitory...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-25 | PXD046422 | Pride
T cells  co-stimulation  gitr  ox40  abin1  ms 
ProteomicsCMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology
Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here, we show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor (...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-02 | PXD036366 | Pride
Cmtm4 Il-17 receptor signaling complex Il-17a Il-17rc 
ProteomicsSystematic analysis of IL-17 receptor signalosome reveals a robust regulatory feedback loop
IL-17 mediates immune protection from fungi and bacteria as well as it promotes autoimmune pathologies. However, the regulation of the signal transduction from the IL-17 receptor (IL-17R) remained elusive. We developed a novel mass spectrometry-based approach to identify components of the IL-17R com...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-15 | PXD019020 | Pride
Traf6 Lubac   Il-17 Ikkε Tbk1 
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