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UnknownStandardized Profiling of The Membrane-Enriched Proteome of Mouse Dorsal Root Ganglia (DRG) Provides Novel Insights Into Chronic Pain.
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S-EPMC5083083 | biostudies-literature
ProteomicsDeep proteome profiling of dorsal root ganglia after nerve injury deciphers shared signatures in adolescent and adult male and female mice
Our understanding of how sex and age influence pathological pain at the molecular level is still limited. This is of high relevance for pediatric and adolescent patients, as they are known to be particularly vulnerable to long-term consequences of pathological pain. Here, we leveraged deep proteome ...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-19 | PXD055816 | Pride
Pediatric Neuropathic pain Proteomics Chronic pain Mefisto Peripheral nervous system Sex similarities Nerve injury Dorsal root ganglia Proteome 
UnknownComparison of the Rat and Human Dorsal Root Ganglion Proteome.
Not available
S-EPMC6128859 | biostudies-literature
TranscriptomicsIntegrated Analysis of Transcriptome and Secretome of Sensory Neurons Reveals Sex Difference in Pathways Relevant to Insulin Sensitivity and Insulin Secretion
Sensory neurons in the dorsal root ganglia (DRG) convey somatosensory and metabolic cues to the central nervous system and release substances locally from stimulated terminal endings in peripheral organs. Sex-biased variations driven by the sex chromosome complement (XX and XY) have been implicated ...
ORGANISM(S): Mus musculus 
2023-09-20 | GSE228189 | GEO
ProteomicsQuantitative proteomic analysis of oxaliplatin induced peripheral neurotoxicity
We performed a data independent acquisition (DIA) -based quantitative proteomics strategy to investigate the global proteome alteration in the dorsal root ganglion (DRG) tissues from mice injected with oxaliplatin for different periods.
ORGANISM(S): Mus musculus (Mouse) 
2022-07-11 | PXD031322 | Pride
Metabolism Peripheral neurotoxicity Oxaliplatin Ros Quantitative proteomics 
UnknownTranscriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion.
Not available
S-EPMC10503313 | biostudies-literature
ProteomicsMouse DRG incision injury versus sham_DIA-MS
Acute pain after surgery is still managed insufficiently. One major need is, therefore, the identification of new targets specifically relevant for postoperative pain to develop effective and non-addictive analgesics. To this end, we have used the plantar incision model in male mice and DIA-MS to re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022706 | Pride
Pain Dia-ms Drg Incision injury 
ProteomicsProteomics on Nav1.8-positive nociceptors of mouse DRG
Nociceptors play an essential role in both acute pain and chronic pain conditions. In this study, we examined the proteome of mouse dorsal root ganglia and compared NaV1.8Cre+/-; ROSA26-flox-stop-flox-DTA (Diphtheria toxin fragment A) mutant mice (NaV1.8Cre-DTA), in which NaV1.8-positive neurons (ma...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-03 | PXD034447 | Pride
Proteomics Mouse drg Ms Nociception 
UnknownMitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics.
Not available
S-EPMC8720329 | biostudies-literature
ProteomicsA sub-compartment proteome for murine sensory neurons
We applied TurboID-based proximity labelling restricted to Advillin-expressing neurons to systematically profile the proteomes of distinct neuronal subcompartments, using parallel accumulation–serial fragmentation combined with data-independent acquisition (diaPASEF) mass spectrometry. Neuronal comp...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-14 | PXD062198 | Pride
Sensory neuron Dia-ms Dorsal root ganglia Pns Turboid 
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