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ProteomicsSUMOylation proteomic analysis of renal cortical collecting duct cells
We profiled SUMO1 and SUMO2 modified proteins in cortical collecting duct (mpkCCD) as a precursor to targeted approaches to assess SUMO function. SUMO levels in cells following heat shock and treatment with deSUMOylation inhibitors were assessed.
ORGANISM(S): Mus musculus (Mouse) 
2019-10-07 | PXD013346 | Pride
Collecting duct Renal Kidney Sumoylation 
ProteomicsQuantitative proteomic analysis of SUMOylation in renal cortical collecting duct cells after aldosterone stimulation
SILAC was employed to investigate the effect of aldosterone stimulation on SUMOylation of cortical collecting duct (mpkCCD) cells.
ORGANISM(S): Mus musculus (Mouse) 
2019-10-07 | PXD013363 | Pride
Collecting duct Quantitative Renal Silac Kidney Sumoylation 
ProteomicsQuantitative Phosphoproteomic Identification of Novel Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells
The kidney distal convoluted tubule (DCT) plays an important role in body sodium regulation and thus control of blood pressure. The main sodium reabsorption pathways in the DCT are the epithelial sodium channel (ENaC) and the thiazide-sensitive NaCl cotransporter (NCC), the functions of which can be...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001729 | Pride
Phosphoproteomics Vasopressin Signaling networks Quantitation Kidney distal convoluted tubule cells 
ProteomicsQuantitative proteomic analysis of urinary exosomes from patients with primary aldosteronism that underwent fludrocortisone suppression test
The sodium chloride cotransporters (NCC) and the epithelial sodium channel (ENaC) have been reported to be the main effectors of aldosterone in Na+ and Cl- reabsorption in the distal nephron and dietary K+ downregulates NCC. The Cl-/HCO3- exchanger pendrin has been revealed as a key role in maintain...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD017083 | Pride
Human Exosomes Urine Kidney 
ProteomicsQuantitative proteome of urinary extracellular vesicles (uEVs) from hypertensive patients with raised aldosterone-to-renin ratios (ARRs) that underwent seated saline suppression testing (SSST)
This dataset contains quantitative proteome from Tandem Mass Tag (TMT) based quantitative proteomic analysis on uEVs from hypertensive patients with raised aldosterone-to-renin ratios (ARR) that underwent seated saline suppression testing (SSST).
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD022653 | Pride
Human Urine Urinary extracellular vesicle Kidney 
ProteomicsAcute effects of Salbutamol in Mouse Kidney Distal Convoluted Tubules (mpkDCT) Cells
The sympathetic nervous system (SNS) plays a central role in blood pressure regulation. Recent studies have shown that cells of the distal convoluted tubule (DCT) can be stimulated directly via the beta-adrenergic receptor resulting in activation of the NaCl cotransporter NCC. Whether these effects ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-17 | PXD019051 | Pride
Beta2-adrenergic receptor Salbutamol Hypertention Dct 
ProteomicsEffects of the differential K+ diets on mouse kidney cortex tissue
In this project, we investigated the global proteome alteration in mouse kidney cortex tissues after differential K+ diet treatments. TMTpro labeling strategy was used to obtain protein quantification information from LC-MS based proteomic analysis.
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD035354 | Pride
Potassium Mouse Kidney 
ProteomicsComparative proteomic analysis of kidney distal convoluted tubule and cortical collecting duct cells following long-term hormonal stimulation
The distal convoluted tubule (DCT) and the cortical collecting ducts (CCD) are portions of renal tubule that are partly responsible for maintaining the systemic concentrations of potassium, sodium, calcium and magnesium. Despite being structurally similar, DCT and CCD cells have different transport ...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-15 | PXD005454 | Pride
Distal convoluted tubule Mouse Hormone Kidney Cortical collecting duct Long-term 
ProteomicsProtein quantification of mouse inner medulla (IM) sections using MS based proteomics - WT vs. Dicer(AQP2Cre+) mice
In this project we investigated the global proteome alteration of dissected mouse inner medulla (IM) sections between the WT and the Dicer(AQP2Cre+) mice. TMT labeling strategy was used to obtain protein quantification information from LC-MS based proteomic analysis.
ORGANISM(S): Mus musculus (Mouse) 
2021-05-05 | PXD022327 | Pride
Dicer Endoribonuclease Aqp2 Im 
ProteomicsProteomic profiling of ubiquitylated proteins in urinary exosomes
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated, but that ubiquitin is cleaved by specific...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080269 | MassIVE
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