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ProteomicsUbiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation. We carried out a proteomic analysis of a B cell lymphoma-derived cell line, BJAB, that requires UBQLN1 for survival to identify UB...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-25 | PXD007610 | Pride
Mitochondrial Tmt Cytosol B cells 
ProteomicsMaternal iron deficiency modulates placental transcriptome and proteome in mid-gestation of mouse pregnancy
Background: Maternal iron deficiency (ID) is associated with poor pregnancy and fetal outcomes. The effect is thought to be mediated by the placenta but there is no comprehensive assessment of placental response to maternal ID. Additionally, whether the influence of maternal ID on the placenta diffe...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-12 | PXD023454 | Pride
Iron deficiency Gene expression Placenta 
ProteomicsThiol-Based Direct Threat Sensing by the Stress-Activated Protein Kinase Hog1
The stress-activated protein kinase Hog1 is best known for its role in osmotic stress but is also activated by a variety of mechanistically distinct environmental stressors including heat shock, ER stress, and arsenic. In the osmotic stress response, the signal is sensed upstream and relayed to Hog1...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-12-04 | PXD015325 | Pride
Arsenic stress Yeast Tmt 
ProteomicsGlobal proteomics of Ubqln2-based murine models of ALS
Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that acts on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like (...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-01-20 | PXD021991 | Pride
Proteomics Als Ubqln2 Proteasome Ubiquitin ligase Neurodegeneration Ubiquitin 
ProteomicsChromatin accessibility promotes hematopoietic and leukemia stem cell activity
Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and nucleosomes. We found that the chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differenti...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-25 | PXD017054 | Pride
Hmgn1 Chromatin Leukemia Aml 
ProteomicsMulti-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Mitonuclear communication is essential to maintain cellular and organismal homeostasis in equilibrium and stress. Mitochondrial stress activates a concerted mitonuclear response geared to safeguard and repair mitochondrial function and to adapt cellular metabolism to the stress. However, the common ...
ORGANISM(S): Homo sapiens (Human) 
2017-06-01 | PXD006293 | Pride
Atf4 Omics Mitochondria Human Orbitral fusion 
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
ProteomicsUBE2O remodels the proteome during terminal erythroid differentiation
Terminal differentiation is characterized by a respecification of the global protein complement, as epitomized by erythrocytes, whose cytosol is ~98% globin. Remodeling of the proteome involves programmed elimination of generic cellular constituents in parallel with synthesis of cell-type-specific p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-08-08 | PXD005904 | Pride
Red blood cell Proteomics Ms3 Tmt Ube2o Proteasome Ubiquitin 
ProteomicsAltered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia
Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in hi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD010924 | Pride
Chronic lymphocytic leukemia Translational fidelity Ribosomal decoding center Cll Rps15 Proteostasis 
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
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