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ProteomicsHepG2 GalNAc-T1/2 Bump-and-hole secretome glycopeptide data
Engineered GalNAc-T glycosyltransferases were used to incorporate a chemically modified GalNAC analog into the secretome of HepG2 cells. The chemical modification included a bioorthogonal alkyne tag that allowed for introduction of a clickable, acid-cleavable biotin-picolyl-azide. Glycoproteins were...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018048 | Pride
Human Bioorthogonal Galnac-t Liver Glycopeptide Click Secretome Hepg2 
ProteomicsHepG2 secretome tagged with the sugar analogs GalNAz and GalNAzMe
Chemically modified analogs of GalNAc, termed GalNAz or GalNAzMe, were incorporated in secreted glycoproteins. The compounds contain bioorthogonal, clickable functional groups that allowed for enrichment using biotin. Chemical glycoproteomics was performed after on-bead digestion and cleavage of gly...
ORGANISM(S): Homo sapiens (Human) 
2020-09-14 | PXD020648 | Pride
Glycosylation Bioorthogonal Mucin Chemical proteomics Enrichment Biotin 
ProteomicsK-562 GalNAc-T1/2 Bump-and-hole Whole cell lysate proteomics data
Engineered GalNAc-T glycosyltransferases were used to incorporate a chemically modified GalNAc analog into the glycoproteins on the cell surface of K-562 cells. The chemical modification included a bioorthogonal alkyne tag that allowed for introduction of a clickable, acid-cleavable biotin-picolyl-a...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017989 | Pride
Human Mucin Bioorthogonal Galnac-t Click Glycoprotein K-562 
UnknownTumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma.
Not available
S-EPMC10313378 | biostudies-literature
UnknownDistinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies.
Not available
S-EPMC9816818 | biostudies-literature
ProteomicsPhosphoproteomics of rodent exercise models
Exercise stimulates systemic and tissue-specific adaptations that protect against lifestyle related diseases including obesity and type 2 diabetes. Exercise places high mechanical and energetic demands on contracting skeletal muscle, which require finely-tuned protein post-translational modification...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-07-22 | PXD010452 | Pride
Skeletal muscle Signal transduction Exercise Phosphoproteomics 
ProteomicsCell-type specific tagging of glycoproteins in murine-human co-culture samples
We report a strategy termed Bio-Orthogonal Cell line-specific Tagging of Glycoproteins (BOCTAG). Cells are equipped by transfection with an artificial biosynthetic pathway (mut-AGX1/NahK/Nh-GalNAc-T2) that transforms an alkyne tagged sugar into the corresponding nucleotide-sugar. Only transfected ce...
ORGANISM(S): Homo sapiens (Human) 
2022-09-10 | PXD035438 | Pride
Mcf7 Co-culture  lfq Proteomics Human-murine 4t1 Secretome 
ProteomicsCell-type specific tagging of glycoproteins in murine-human co-culture secretome glycoproteomics
We report a strategy termed Bio-Orthogonal Cell line-specific Tagging of Glycoproteins (BOCTAG). Cells are equipped by transfection with an artificial biosynthetic pathway (mut-AGX1/NahK/Nh-GalNAc-T2) that transforms an alkyne tagged sugar into the corresponding nucleotide-sugar. Only transfected ce...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-09-10 | PXD035445 | Pride
Mcf7 Human-murine 4t1 Secretome Co-culture  glycoproteomics 
ProteomicsCell-type specific tagging of glycoproteins in murine-human co-culture samples glycoproteomics lysates
We report a strategy termed Bio-Orthogonal Cell line-specific Tagging of Glycoproteins (BOCTAG). Cells are equipped by transfection with an artificial biosynthetic pathway (mut-AGX1/NahK/Nh-GalNAc-T2) that transforms an alkyne tagged sugar into the corresponding nucleotide-sugar. Only transfected ce...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-09-10 | PXD035449 | Pride
Mcf7 Human-murine Lysate 4t1 Co-culture  glycoproteomics 
UnknownUnderstanding the Effectiveness of Water, Sanitation, and Hygiene Interventions: A Counterfactual Simulation Approach to Generalizing the Outcomes of Intervention Trials.
Not available
S-EPMC11661469 | biostudies-literature
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