Sort   by:  
 Page size 
ProteomicsProteomic Analysis of a PLK1-Dependent, Cell Cycle Degradation Program
Targeted protein degradation by the ubiquitin-proteasome system is an essential mechanism regulating cellular division. The kinase PLK1 coordinates protein degradation at the G2/M phase of the cell cycle by promoting the binding of substrates to the E3 ubiquitin ligase SCFβTrCP. However, the magnitu...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046039 | Pride
Degradation Plk1 Cell cycle Ubiquitin 
UnknownGenotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study.
Not available
S-EPMC3158597 | biostudies-literature
ProteomicsThe synaptic proteome and phosphoproteome is uniquely vulnerable to sleep loss during brain development while maturation confers resilience
Sleep supports lifelong brain health and cognition. Sleep loss in early life can drive lasting changes in adult behavior, indicating sleep plays a distinct but poorly understood role supporting brain development. We systematically examined the molecular and behavioral adaptations and synaptic conseq...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-08 | PXD047381 | Pride
Synapses  brain development  sleep  sleep deprivation 
ProteomicsFOXA1 proximity labeling reveals novel interactions with NR2C2 in ER+ breast cancer
Approximately 75% of breast cancers are driven by the estrogen receptor alpha (ER), and despite the advent of endocrine therapy to block ER signaling pathways, a significant portion of women develop resistance to these drugs. The pioneer factor FOXA1 has been shown to facilitate nearly all DNA-bindi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD046652 | Pride
Nr2c2 Biotin ligase Foxa1 Proximity labeling Breast cancer 
ProteomicsDetermining kinome changes in response to Cytomegalovirus US28 expression and identifying US28 interacting proteins
Cytomegalovirus (CMV) reactivation of latent infection following immune dysregulation remains a serious risk for patients, often causing significant morbidity and mortality. Herein, we demonstrate the CMV-encoded GPCR, US28, in coordination with cellular Ephrin receptor A2 (EphA2), attenuates MAPK s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033391 | Pride
Viral infection Affinity purification-mass spectrometry Kinome 
ProteomicsSETD2 N-terminus mediates interaction with Lamins
Histone-Lysine N-methyltransferase SETD2 is an evolutionarily conserved histone methyltransferase that associates with RNA Polymerase II (RNAPII) and catalyzes trimethylation of histone H3 lysine 36 (H3K36me3) in transcribed regions. Interestingly, SETD2 is frequently mutated in cancers. Clear cell ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD040771 | Pride
Setd2 Cdk1 Mitosis Lamin 
ProteomicsIdentification of GRAF1 interactome mediated by GRAF1 phosphorylation in response to Mitophagy
Defects in the clearance of dysfunctional mitochondria contribute to the development of heart failure and several neurological disorders including Parkinson’s disease (PD). The mitophagic signaling pathways that control the rapid recognition, ubiquitin-tagging and encasement of dysfunctional mitocho...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD043212 | Pride
Heart Graf1 Pink1-parkin pathway Mitophagy 
ProteomicsProteomic analysis of Eya3 binding partners
Eyes absent homolog 3 (EYA3) is a transcriptional cofactor that is known to partner with the sine oculis homeobox (SIX) family to regulate gene expression. In this study, we characterized a novel splice isoform of EYA3, including the alternative cassette exon 7 (EYA3+ex7), that becomes more highly e...
ORGANISM(S): Homo sapiens (Human) 
2023-10-13 | PXD037572 | Pride
Transcription Eya3 Alternative splicing Myogenesis 
ProteomicsProximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion.
In this study, we are the first to use the MiniTurboID generation of the proximity-dependent biotin identification (BioID) technology to illuminate how the lymphatic endothelial cell (LEC) VE-cadherin interactome changes during junctional remodeling in response to the lymphangiocrine factor adrenome...
ORGANISM(S): Homo sapiens (Human) 
2024-09-05 | PXD040452 | Pride
Ve-cadherin Exocyst Lymphatic endothelial cells Adherens junctions Reelin Bioid 
ProteomicsIdentification of SAFB and HnrnpU interactors
Scaffold Attachment Factor B (SAFB) is a conserved RNA Binding Protein (RBP) that is essential for early mammalian development. However, the RNAs that associate with SAFB in mouse embryonic stem cells have not been characterized. Here, we addressed this unknown using RNA-seq and SAFB RNA immunopreci...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD038103 | Pride
Stem cell Development Rna binding proteins 
Sort   by:  
 Page size