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ProteomicsHepG2 HLA-I immunopeptidome by immunoprecipitation
This study utilized mass spectrometry-based proteogenomic profiling to identify the HLA-I immunopeptidome enriched from HepG2 cell. HepG2 WES-based and the COSMIC-based mutation database were generated and utilized to identify HepG2-specific mutant immunopeptides
ORGANISM(S): Homo Sapiens 
2023-09-07 | PXD045203 |
ProteomicsIncreased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity
HLA-presented antigenic peptides are central components of T cell-based immunity in infectious disease. Beside HLA molecules on cell surfaces, soluble HLA molecules (sHLA) are released in the blood suggested to impact cellular immune responses. We demonstrated that sHLA levels were significantly inc...
ORGANISM(S): Homo sapiens (Human) 
2022-11-23 | PXD029567 | Pride
Covid-19 Immunopeptidome Soluble hla 
ProteomicsMachine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome
HLA-DQ molecules can be formed as both cis and trans variants. So far, the progress for predicting HLA-DQ antigen presentation has been limited. In addition, the contribution of trans-only variants in shaping the HLA-DQ immunopeptidome remains largely unresolved. Here, we address these issues by int...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040860 | Pride
Machine learning Immunopeptidome Hla-dq 
ProteomicsT1D B lymphocyte cell line Immunopeptidome
HLA-I and HLA-II immunopeptidome of B cells from healthy control and Type 1 diabetics sharing similar HLA alleles.
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD026184 | Pride
Hla-ii B cell T1d Immunopeptidome Hla-i Human Allele 
ProteomicsProteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma
Immune checkpoint inhibitor and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential for cancers with high tumor mutation burden (TMB). Here, we employed mass spectrometry (MS)-based proteogenomic large-scale profiling to identify potential immunogenic human leukocyte ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD022949 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
ProteomicsKinase inhibition rewires the HLA-I immunopeptidome in Chronic Myeloid Leukemia
Antileukemia immunity is essential for disease control and maintaining treatment-free remission in chronic myeloid leukemia (CML). Immunotherapeutic approaches hold significant promise for enhancing immune-mediated disease control. However, successful immunotherapy relies on identifying CML-associat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD076608 | Pride
Kinase inhibitors Immunopeptidomics Proteomics Cml 
ProteomicsThe HLA ligandome comprises a limited repertoire of O-GlcNAcylated antigens preferentially associated with HLA-B07:02
Mass-spectrometry based immunopeptidomics has provided unprecedented insights into antigen presentation, not only charting an enormous ligandome of self-antigens, but also cancer neo-antigens and peptide antigens harbouring post-translational modifications. Here we concentrate on the latter, focusin...
ORGANISM(S): Homo sapiens (Human) 
2021-12-03 | PXD028874 | Pride
O-glcnacylation Hla-b07 Mhc Hla class i Immunopeptidomics 
ProteomicsThe immunopeptidome of HLA-DR from PBMC
Quantifiying the impact of initial cell counts on the identified HLA-DR immunopeptidome of PBMC.
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD023032 | Pride
Pbmc Hla-ii Immunopeptidome Human blood Hla-dr 
ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstrat...
ORGANISM(S): Homo sapiens (Human) 
2021-12-06 | PXD017922 | Pride
Hla Post-translational modification Mass spectrometry Immunopeptidome Proteasome Spliced peptides 
ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstra...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD009660 | Pride
Hla Post-translational modification Mass spectrometry Immunopeptidome Proteasome Spliced peptides 
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