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TranscriptomicsGSI, Human T-ALL
The NOTCH signaling cascade, which is deregulated in T-cell acute lymphoblastic leukemia (T-ALL) and many other human cancers, offers an attractive target for molecular therapy. One approach employs gamma-secretase inhibitors (GSIs) to suppress production of the intracellular form of NOTCH (NICD), ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-8416 | biostudies-arrayexpress
MetabolomicsRANCM: a new ranking scheme for assigning confidence levels to metabolite assignments in NMR-based metabolomics studies

INTRODUCTION: The Metabolomics Standards Initiative has recommended four categories for metabolite assignments in NMR-based metabolic profiling studies. The putatively annotated compound category is most commonly reported by metabolomics investigators. However, there is significa...

2019-09-27 | MTBLS781 | MetaboLights
ProteomicsWhole Proteomics of 24 hr pan Pim kinase inhibitor treatment of IL2 cultured CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051214 | Pride
Lc-msms Pim447 Azd1208 Tofacitinib Mouse Pim1 Pim2 Cd8 t cell Cytotoxic t lymphocyte Pim kinase 
UnknownIncisional hernia following colorectal cancer surgery according to suture technique: Hughes Abdominal Repair Randomized Trial (HART).
Not available
S-EPMC10364691 | biostudies-literature
ProteomicsAnalysis of the interactome of the RLTPR/CARMIL2 protein in CD4+ T cells
We analyzed the interactome of the mouse protein RLTPR (CARMIL2) using an affinity purification method based on the introduction of a One-Strep-tag (OST) sequence in the C-terminus of the bait protein by genetic engineering of primary mouse T cells. We used mouse models expressing the tagged version...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD055893 | Pride
Ap-ms Primary t cell Rltpr Interactome Ost tag Carmil2 
TranscriptomicsTranscription profiling of activated or unactivated T cells isolated from peripheral human leukocytes under gravity or vectorless gravity conditions
Peripheral blood leukocytes of three human donors (Donors 2, 4, and 5) were isolated from blood bank buffy-coat preparations by Ficoll-Hypaque density gradient centrifugation, and T-cells were purified with high affinity negative selection human CD3+ T-cell enrichment columns. The cells were resusp...
ORGANISM(S): Homo sapiens 
2007-06-25 | E-GEOD-1709 | biostudies-arrayexpress
ProteomicsProteomics of 24 h TCR activated wild-type and Pim1/Pim2 double knockout CD4 and CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051198 | Pride
Lc-msms Mouse Pim1 Pim2 T lymphocyte Pim kinase 
UnknownLineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.
Not available
S-EPMC2211402 | biostudies-literature
ProteomicsAnalysis of CD2 interactome in primary murine CD4+ T cells
CD2 is a receptor expressed on T cells and when engaged, it promotes T cell activation. However the mechanisms and molecular partners of CD2 that mediate T cell activation remain unclear. Here we used AP-MS to determine the interactome of CD2 prior and upon its engagement. For this purpose, we used ...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-12 | PXD029750 | Pride
Cd2 Ap-ms Mouse Primary cd4+ t cell Interactome Ost tag 
ProteomicsDefining the T cell proteome and the role of mTORC1 during differentiation using quantitative proteomics
High-resolution quantitative mass-spectrometry reveals similarities and disparities in how murine naïve CD4 and CD8 T cells respond to immune activation and re-structure proteomes as they differentiate to effector cells. The data map core transcriptional, metabolic and protein synthesis machinery, n...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-28 | PXD012058 | Pride
Mouse T cell Mtorc1 Fusion Tmt Mtor Rapamycin 
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