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ProteomicsBioID Assay of BirA*-hARGLU1 or BirA*-hGR in Flp-In T-Rex 293 cells
ARGLU1 is a Transcriptional Coactivator and Splicing Regulator Important for Stress Hormone Signaling and Development Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modu...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD012555 | Pride
Nr3c1 Splicing Gr Arglu1 
ProteomicsARGLU1 RIME experiment in N2a cells
ARGLU1 is a Transcriptional Coactivator and Splicing Regulator Important for Stress Hormone Signaling and Development Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modu...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-15 | PXD012406 | Pride
Nr3c1 Splicing Gr Arglu1 
ProteomicsOptimal Dissociation Methods Differ for N- and O-glycopeptides
Site-specific characterization of glycosylation requires intact glycopeptide analysis, and recent efforts have focused on how to best interrogate glycopeptides using tandem mass spectrometry (MS/MS). Beam-type collisional activation, i.e., higher-energy collisional dissociation (HCD), has been a val...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2020-07-20 | PXD017646 | Pride
Glycoproteomics N-glycopeptides Scehcd Ethcd O-glycopeptides Etd 
ProteomicsDiscovery of a pathway for endogenous mucin glycodomain catabolism in mammals
Mucins are functionally implicated in a range of human pathologies, including cystic fibrosis, influenza, bacterial endocarditis, gut dysbiosis, and cancer. These observations have motivated the study of mucin biosynthesis as well as development of strategies for inhibition of mucin glycosylation. M...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-09-03 | PXD027616 | Pride
Human Catabolism Glycoproteomics Mucins Mucinase 
ProteomicsModulation of immune cell reactivity with cis-binding Siglec-9 agonists
Primary inflammatory pathologies caused by phagocytes lead to numerous debilitating conditions, ranging from chronic pain to permanent blindness. Siglec-9 is an immunoinhibitory receptor expressed on many types of phagocytes and is a promising target for anti-inflammatory therapeutics. We developed ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD018774 | Pride
Phosphoproteomics Tmt Lc-ms/ms 
ProteomicsThermal Proteome Prodiling and Glycoproteomics of U937 cells
Protein glycosylation regulates essential cellular processes including protein folding, stability, and cell-cell interactions; however, how aberrant glycosylation impacts protein function and interaction networks remains poorly understood. Here we combine mass spectrometry-based proteomics, chemical...
ORGANISM(S): Homo sapiens (Human) 
2025-12-11 | PXD071666 | Pride
Human monocytes with perturbed secretory pathway 
ProteomicsAAV delivered lysosome-targeting chimeras mediate sustained antibody depletion in vivo (absolute IgG quantification)
Genetically-encoded lysosome targeting chimeras (GELYTACs) were developed against circulating IgGs. To achieve long-lasting IgG depletion, GELYTACs were encoded in an AAV gene therapy vector and continuous expression in mice was established. To assess the efficiency of IgG depletion and subclass bia...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-05 | PXD079901 | Pride
Absolute quantification Lytac Antibodies 
ProteomicsIntergenerational and biochemical responses of the Western honey bee (Apis mellifera) to sublethal perfluorooctane sulfonate (PFOS) exposures.
Bees are threatened by multiple stressors, including environmental contaminants such as perfluorooctane sulfonate (PFOS). In this exposure effect study, small whole colonies of A. mellifera (2500 bees) were exposed to sublethal PFOS concentrations (5 to 20 µg L-1 in sugar syrup) over a 25-day period...
ORGANISM(S): Apis mellifera (Honeybee) 
2026-03-18 | PXD070054 | Pride
Ecotoxicity Proteomics Honey Effects study Bee colony Oxidative stress Pfas Cage Bee. 
UnknownWhole genome sequence analyses of brain imaging measures in the Framingham Study.
Not available
S-EPMC5772158 | biostudies-literature
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