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ProteomicsHigh-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor
While international consensus and the 2021 WHO classification recognize multiple molecular medulloblastoma subgroups, these are difficult to identify in current clinical practice. As a result, biology driven risk stratification and therapy assignment for medulloblastoma constitutes a major challenge...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD051235 | Pride
Proteomics Medulloblastoma Myc Immunohistochemistry 
ProteomicsHigh-resolution proteomic analysis of medulloblastoma clinical samples identifies therapy resistant subgroups and MYC immunohistochemistry as a powerful outcome predictor
While international consensus and the 2021 WHO classification recognize multiple molecular medulloblastoma subgroups, these are difficult to identify in current clinical practice. As a result, biology driven risk stratification and therapy assignment for medulloblastoma constitutes a major challenge...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD051319 | Pride
Medulloblastoma Dia Proteomics Myc Immunohistochemistry 
ProteomicsMapping in silico genetic networks of tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities
Cancers harbouring loss-of-function (LOF) alterations in tumour suppressor genes lack targeted therapies, thus alternative means to characterise gene function and identify vulnerabilities in these cancer cells are required. Here, we map the in silico genetic networks of KMT2D, a frequently mutated t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD048272 | Pride
Metabolism Kmt2d Immune checkpoint inhibitor Genetic networks Synthetic lethality 
ProteomicsCLK IP-MS - CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
CLK kinase was immunoprecipitated using differential tagging of the N- and C-terminus
ORGANISM(S): Homo sapiens (Human) 
2017-03-14 | PXD003839 | Pride
Kinase Immunoprecipitation Tandem mass tag 
ProteomicsAn RNA Splicing System that Excises DNA Transposons from Animal mRNAs
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects C. elegans and human genes from DNA transposon-mediated disruption by excising these TEs from host mRNAs. SOS splicing, which operates independently of...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD068578 | Pride
Affinity purification 
ProteomicsSmall molecule inhibitors of eIF4A1/2 impair the oxidative stress response in osteosarcoma cells to block tumor growth and metastatic capacity
Effective therapies for metastatic osteosarcoma (OS) remain a major clinical unmet need. Targeting mRNA translation in metastatic OS represents an attractive option, as selective translation under stress supports the rapid synthesis of cytoprotective proteins that facilitate metastatic competence. W...
ORGANISM(S): Homo sapiens (Human) 
2024-07-16 | PXD047420 | Pride
Translation inhibitors Oxidative stress Rocaglates Osteosarcoma 
UnknownRandomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma.
Not available
S-EPMC4981979 | biostudies-literature
ProteomicsInvestigating Reporter Ion Signal Characteristics in Isobaric Mass Tag Proteome Quantification Experiments
In this study we sought to examine the characteristics of the reporter ion signal obtained using current generation OT-based MS hardware. We initially focus on re-analysis of a previous experiment where TMT was using in combination with OT-MS3 to study protein expression diversity between histotypes...
ORGANISM(S): Homo sapiens (Human) Ralstonia eutropha JMP134 Yarrowia lipolytica (Candida lipolytica) 
2017-04-26 | PXD005892 | Pride
Ms3 Tmt Orbitrap fusion 
ProteomicsYeast not5 mutant protein translation analysis
Analysis of translation rate and turnover differences between wild type and not5 mutant yeast using pulse-chase mass spectrometry.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-06-01 | PXD003871 | Pride
Silac Turnover Protein synthesis Yeast 
ProteomicsLineage-specific Protein Interactomes of the Hox Transcription Factor Ubx revealed by Close-Proximity Protein Biotinylation
Cell type diversity is controlled by transcription factors (TFs), which regulate specific yet flexible gene expression programs depending on the cellular environment. However, how sets of TFs work together to promote such diversity with high precision is still unknown. We used the Hox TF Ultrabithor...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-04-22 | PXD014481 | Pride
Close-proximity biotinylation Transcription Close-proximity partners Ubx Ppi Drosophila Interaction Interactome Bioid Ultrabithorax Proteomics Development Hox 
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