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ProteomicsUntreated A375 cells vs BRAFi/MEKi-treated A375 cells
Quantitative proteomic analysis in untreated A375 cells and BRAFi/MEKi-treated A375 cells
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD068007 | Pride
Drug-tolerant cells Targeted therapy A375 
ProteomicsS-nitrosylation of p53 in A375 cells
Nitric oxide (NO) is a pleiotropic signaling molecule that affects numerous biological functions. One unique posttranslational modification of proteins by NO is termed S-nitrosylation (SNO), but the role in modulating key proteins’ function in melanoma has not been fully characterized. In the presen...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD031807 | Pride
A375 Mass spectrometry S-nitrosylation P53 Melanoma cells 
TranscriptomicsTNF-α as a key player in Melanoma cell aggressiveness
Purpose. Aggressiveness is a crucial issue related to cutaneous melanoma malignancy and its high metastatic potential. Aim of this work is to identify new pathways or molecules controlling melanoma cell aggressiveness. Proliferation, migration and invasion capability under serum stimulation were an...
ORGANISM(S): Homo sapiens 
2019-01-08 | E-MTAB-4212 | biostudies-arrayexpress
UnknownAnti-Proliferative Effect of Rosmarinus officinalis L. Extract on Human Melanoma A375 Cells.
Not available
S-EPMC4503536 | biostudies-literature
ProteomicsMass spectrometry (MS) datasets of PURPL RNA pulldown samples in A375 cells
We performed PURPL RNA pulldown followed by MS analysis to identify purpl-interacting proteins in A375 cells.With high performance liquid chromatography-mass spectrometry (HPLC-MS), the binding protein of PURPL from RNA pull down was detected by removing non-specific protein which were binding with ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028863 | Pride
Human a375 cells lc-ms 
ProteomicsAnalysis of Amino Acid Variants in Malignant Melanoma Cells Resistant to BRAF inhibition
Analysis of patient-specific nucleotide variants is a cornerstone of personalised medicine. Although only 2% of the genomic sequence is protein-coding, mutations occurring in these regions have the potential to influence protein structure and may have severe impact on disease aetiology. Of special i...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD018305 | Pride
Nucleotide sequencing Melanoma Mass spectrometry Proteogenomics Cancer Brafi resistance Phosphorylation 
ProteomicsPhosphoproteome of shUBE2N in melanoma cells
Quantitative label-free LC-MS/MS was performed on TiO2-enriched phosphopeptides from A375 cells expressing shUBE2N versus shcontrol (n=3 per group).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-25 | MSV000082208 | MassIVE
ProteomicsLC-MS analysis of human melanoma cell line response to eIF4F inhibition and MEK inhibition
The project aimed to identify changes at the protein level in human melanoma cells treated with the eIF4F inhibitor rocaglamide A, the MEK inhibitor PD184352 (CI-1040), and their combination. A375 and MelJuso human melanoma cell lines were cultured in RPMI 1640 medium supplemented with 10% fetal bov...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD073251 | Pride
Eif4a Human Inhibitor Rocaglamide a Small-molecule Ci-1040 Melanoma Pd184352 Cell line Meljuso A375 Lc-ms Eif4f Mek 
ProteomicsMAGE-A4 TCR-like antibody immunoprecipitation in A375 and A375 MAGE-A4 KO xenograft tissue
To demonstrate the on-target binding of the MAGE-A4 antibody to the target HLAp GVYDGREHTV, we developed a reverse immunopeptidomics strategy that uses the HLAp-targeting antibody as a bait to enrich interacting HLAp from A375 xenografts. For this purpose, we immobilized the IgG-format of the MAGE-A...
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD048298 | Pride
Tcr-like antibody Human tissue Immunopeptidomics 
ProteomicsMAGE-A4 TCR-like antibody immunoprecipitation in A375 and A375 MAGE-A4 KO xenograft tissue
To demonstrate the on-target binding of the MAGE-A4 antibody to the target HLAp GVYDGREHTV, we developed a reverse immunopeptidomics strategy that uses the HLAp-targeting antibody as a bait to enrich interacting HLAp from A375 xenografts. For this purpose, we immobilized the IgG-format of the MAGE-A...
ORGANISM(S): Homo sapiens (Human) 
2024-03-30 | PXD048297 | Pride
Tcr-like antibody Human tissue Immunopeptidomics 
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