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ProteomicsHepG2 HLA-I immunopeptidome by immunoprecipitation
This study utilized mass spectrometry-based proteogenomic profiling to identify the HLA-I immunopeptidome enriched from HepG2 cell. HepG2 WES-based and the COSMIC-based mutation database were generated and utilized to identify HepG2-specific mutant immunopeptides
ORGANISM(S): Homo Sapiens 
PXD045203 |
UnknownMurine xenograft bioreactors for human immunopeptidome discovery.
Not available
S-EPMC6898210 | biostudies-literature
ProteomicsHuman NDMM MHC-I immunopeptidome mass spectrometry
To assess the contribution of ribosome profiling-detected nuORFs in NDMM to the MHC-I immunopeptidome and their potential for generating neoantigens, we obtained MHC-I immunopeptidome mass spectrometry (MS/MS) spectra from three patients with NDMM.
ORGANISM(S): Homo sapiens (Human) 
2025-02-20 | PXD047053 | Pride
Human Ndmm Mhc-i Lc-ms/ms 
ProteomicsEditing the immunopeptidome of melanoma cells using a potent inhibitor of ER aminopeptidase 1
The efficacy of cancer immunotherapy, including treatment with immune-checkpoint inhibitors, is often limited by ineffective presentation of antigenic peptides that can elicit T-cell mediated anti-tumor cytotoxic responses. Therefore, manipulating antigen presentation is an emerging approach for enh...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD011766 | Pride
Inhibitor Immunopeptidome Erap1 
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-19 | PXD008733 | Pride
Tissue Mass spectrometry Mhc Immunopeptidome Map 
UnknownHLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses.
Not available
S-EPMC9731565 | biostudies-literature
ProteomicsSILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor-treated and resistant tumor cells
The immunopeptidome is constantly monitored by T cells to detect foreign or aberrant HLA peptides. It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. To precisely determine how cha...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054097 | Pride
Kinase inhibitor resistance Immunopeptidomics Cancer Mass-spectrometry Cryptic peptides Mapk signaling Melanoma Lc-ms/ms 
ProteomicsT1D B lymphocyte cell line Immunopeptidome
HLA-I and HLA-II immunopeptidome of B cells from healthy control and Type 1 diabetics sharing similar HLA alleles.
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD026184 | Pride
Hla-ii B cell T1d Immunopeptidome Hla-i Human Allele 
UnknownThe Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases.
Not available
S-EPMC6944237 | biostudies-literature
ProteomicsER stress and dsRNA sensing with Rt3D and palbociclib - Immunopeptidome
Cytoplasmic pattern recognition receptors (PRRs) for double-stranded RNA (RIG-I/MDA5) are key mediators of anti-viral responses. PRR agonists, such as dsRNA oncolytic Reovirus type 3 Dearing (Rt3D), potently activate RNA sensors. We used an unbiased cytotoxicity screen to reveal synergistic drug-vir...
ORGANISM(S): Homo sapiens (Human) 
2025-05-02 | PXD036559 | Pride
A375 Tmtpro Immunopeptidome 
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