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TranscriptomicsExpression data of CD4+T cells from Idiopathic CD4+ T cells lymphopenia (ICL) patients, Sarcoidosis (SARC) and Healthy individuals
This work focuses on understanding the molecular basis of the immune dysfunctions in Idiopathic CD4+ T cells lymphocytopenia (ICL). ICL is a rare haematological disorder of unknown origin, characterized by a profound and persistent CD4+ T-cell defect, which predisposes to life threatening opportunis...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-56998 | biostudies-arrayexpress
ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links part 2 of 2: AP-MS DATA (QUBIC)
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-13 | MSV000079577 | MassIVE
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD024280 | Pride
Scai Xenopus Interstrand crosslink repair Chromass Dna damage Icl Fanci Fancd2 
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation (total proteome)
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD029409 | Pride
Scai Xenopus Total proteome Interstrand crosslink repair Npe Dna damage Icl Fanci Fancd2 
ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links, part 1 of 2: CHROMASS DATA
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2015-05-07 | PXD000490 | Pride
Icl repair Chromatin Stalled replication forks Dna damage response 
ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links part 2 of 2: AP-MS DATA (QUBIC)
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Homo sapiens (Human) 
2015-05-07 | PXD000491 | Pride
Icl repair Chromatin Stalled replication forks Dna damage response 
ProteomicsATM promotes reversed fork processing during DNA interstrand cross-link repair
During replication-coupled DNA interstrand cross-link (ICL) repair, fork reversal is thought to enable the Fanconi anemia (FA) pathway to resolve the ICL through nucleolytic incisions. Subsequent fork restoration then allows nascent DNA strand extension past the lesion. Although these fork remodelin...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2026-08-25 | PXD071242 | Pride
Fork reversal Interstrand cross-link Exo1 Icl repair Pp2a Fanconi anemia pathway Dna2 Atm Fork restoration Orbitrap astral mass spectrometer Wrn 
ProteomicsDual role of PCNA-monoubiquitination in facilitating Fanconi Anemia-mediated interstrand crosslink repair
The Fanconi Anemia (FA) repair pathway governs the repair of highly genotoxic DNA interstrand crosslinks (ICLs) with the assistance of translesion synthesis (TLS), that is facilitated by site-specific monoubiquitination of PCNA (PCNA-Ub) at lysine 164 (K164). Mutation at this residue (K164R) renders...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD035337 | Pride
Lc-msms Rime Interstrand crosslink repair Mouse Dna damage tolerance Mismatch repair Fanconi anemia Pcna ubiquitination 
GenomicsBRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage responsefactor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyADP...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-35698 | biostudies-arrayexpress
UnknownThe SNM1A DNA repair nuclease.
Not available
S-EPMC7607226 | biostudies-literature
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