T cells exclusion precludes checkpoint inhibition efficacy in pancreatic ductal adenocarcinoma (PDA) and is mediated by the interaction between T cell CXCR4, and its ligand CXCL12, which is complexed to keratin-19 (KRT19) on the surface of PDA cells. KRT19 secretion is essential to this process but ...
The aqueous humor is a colourless, transparent fluid that fills the anterior chamber of the eye. It has an important role to play in maintaining the intraocular pressure of the eye and providing nourishment to avascular structures such as the lens and cornea. It is also essential for providing a cle...
The aim of this project was to compare and optimize sample processing protocols up-stream of LC-MS/MS. We set out to create a protocol that is easier and less laborious to use with liquid handlers than FASP, but that generates comparable results as FASP or traditional in-gel digestion.
