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ProteomicsPhomopsis amygdala fusicoccadiene synthase
Fusicoccadiene synthase from Phomopsis amygdali (PaFS) catalyzes the first committed step in the biosynthesis of Fusicoccin A, a diterpene glycoside and a a potential therapeutic agent. PaFS contains a C-terminal prenyltransferase domain that generates geranylgeranyl diphosphate (GGPP) and an N-term...
ORGANISM(S): Phomopsis sp. amygdali NY7157a 
2021-07-07 | PXD021007 | Pride
Terpene cyclase Ggpp synthase 
ProteomicsPRR of Tau Crosslinking with Tubulin
We used cross-linking mass spectrometry with the cleavable cross-linker, disuccinimidyl dibutyric urea (DSBU) to map sites of interaction between the proline rich domain (PRR, tau amino acids 149-244) and tubulin. For comparison, we also conducted these experiments with PRR constructs containing mul...
ORGANISM(S): Bos taurus (Bovine) Escherichia coli 
2026-03-09 | PXD049384 | Pride
Tubulin Tau Phosphorylation Proline rich region 
ProteomicsStructure of TFIIK for phosphorylation of CTD of RNA polymerase II
TFIIH is a 10-protein complex that is conserved through out eukaryotes. TFIIH has two primary cellular functions: transcription initiation and nucleotide excision repair (NER). In transcription initiation, TFIIH acts as a structural scaffold, phosphorylates the RNA polymerase II (pol II) C-terminal ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-07 | PXD021211 | Pride
Transcription Tfiik Phosphorylation 
ProteomicsStructure of Saccharomyces cerevisiae Mediator-RNA polymerase II pre-initiation complex for divergent transcription
This study has determined structure of transcription initiation complexes including a DNA-bound activator, RNA polymerase II (Pol II), and Mediator on a divergent promoter GAL80/SUT719 using a combination of cryo-EM and XL-MS analyses. Our cryo-EM single-particle analysis reveals a dimeric form of ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD036149 | Pride
Enhancer Divergent transcription Transcription Mediator Uas Initiation Activator Rna polymerase ii 
ProteomicsA conserved long intergenic non-coding RNA containing snoRNA sequences, lncCOBRA1, affects Arabidopsis germination and development
Long non-coding RNAs (lncRNAs) are an increasingly studied group of non-protein coding transcripts with a wide variety of molecular functions gaining attention for their roles in numerous biological processes. Nearly 6,000 lncRNAs have been identified in Arabidopsis thaliana but many have yet to be ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-12 | PXD033707 | Pride
Lincrna  snorna  rbp  chirp  arabidopsis  development 
ProteomicsStructure of the Hir histone chaperone complex
The evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1/Asf1 co-chaperone cooperate for replication-independent chromatin assembly. Here we report the molecular architecture of the Hir complex with Asf1/H3/H4 via single-particle cryo-EM and crosslinking mass spectrometry.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-08-22 | PXD040705 | Pride
Histone Deposition Xlms Em Dna Chaperone Rna Yeast 
ProteomicsStructure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in Nucleotide Excision Repair
TFIIH is a 10-protein complex that is conserved throughout eukaryotes. TFIIH has two primary cellular functions: transcription initiation and nucleotide excision repair (NER). NER in eukaryotes begins by recognition of a bulky lesion by the obligate dimer Rad4-Rad23. This is followed closely by the ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-07 | PXD021212 | Pride
Dna repair Tfiih Rad4 Rad33 Rad23 Dna damage Nucleotide excision repair 
ProteomicsStructural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module
The Mediator complex consists of a Core and a dissociable Kinase module. This project is to understand the binding mode between the Core and Kinase module. Both Mediator complex and its Kinase module were individually crosslinked and analyzed by XL-MS.
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD044328 | Pride
Human Transcription Mediator Cdk8 
ProteomicsBacterial respiratory cytochrome bc1-cbb3 supercomplex
Cryo-EM Structures of Respiratory bc1-cbb3 type CIII2CIV Supercomplex and Electronic Communication Between the Complexes
ORGANISM(S): Rhodobacter capsulatus 
2021-03-23 | PXD020038 | Pride
Rhodobacter capsulatus Qe hf 
GenomicsDynamic changes of DNA methylome and hydroxymethylome during neural differentiation of hES cell (hMeDIP-Seq and MBD-Seq)
DNA methylation and hydroxymethylation have been implicated in normal development and differentiation, but our knowledge about the genome-wide distribution of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) during cellular differentiation remains limited. Using in vitro model system of gra...
ORGANISM(S): Homo sapiens 
2013-11-04 | E-GEOD-38214 | biostudies-arrayexpress
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