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TranscriptomicsConservation of mRNA and protein expression during development of C. elegans
Spatiotemporal control of gene expression is crucial for development and subject to evolutionary changes. Although proteins are the final product of most genes, the developmental proteome of an animal has not yet been comprehensively defined, and the correlation between RNA and protein abundance dur...
ORGANISM(S): Caenorhabditis elegans 
2014-01-23 | E-GEOD-53359 | biostudies-arrayexpress
TranscriptomicsGlobal characterization of the oocyte-to-embryo transition in C. elegans uncovers a novel mRNA turnover mechanism
The oocyte-to-embryo transition (OET) is thought to be mainly driven by post-transcriptional gene regulation. However, expression of both RNAs and proteins during the OET has not been comprehensively assayed. Furthermore, specific molecular mechanisms that regulate gene expression during OET are lar...
ORGANISM(S): Caenorhabditis elegans 
2014-07-02 | E-GEOD-58141 | biostudies-arrayexpress
ProteomicsGlobal phosphoproteomics elicited by the SCF/KIT axis in human skin mast cells unveil capicua as a potent KIT repressor
Global phosphoproteomics can reveal signaling cascades in unprecedented detail. The SCF/KIT axis represents a vital hematopoietic receptor tyrosine kinase (RTK) system with gain-of-function mutations prompting the development of mastocytosis and leukemia. Here, we employed a label-free phosphoproteo...
ORGANISM(S): Homo sapiens (Human) 
2022-11-15 | PXD028252 | Pride
Phosphoproteome Human Scf Mast cells 
ProteomicsPrdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators
Mutation of the PRDM16 gene causes human dilated and noncompaction cardiomyopathy. The PRDM16 protein is a transcriptional regulator that affects cardiac development via Tbx5 and Hand1, thus regulating myocardial structure. The biallelic inactivation of Prdm16 induces severe cardiac dysfunction with...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-21 | PXD043601 | Pride
Mouse Heart Cardiac metabolism Cardiomyopathy 
ProteomicsCold-induced urticarial autoinflammatoy syndrome related to factor XII activation
Early onset urticarial rash with systemic inflammatory symptoms are hallmarks of hereditary autoinflammatory diseases caused by gene mutations of the innate immune pathway, e.g. nucleotide receptor protein 3 (NLRP3). However, in many cases genetic tests are negative, suggesting the existence of unre...
ORGANISM(S): Homo sapiens (Human) 
2010-01-10 | PXD016341 | Pride
Cleavage Activation Factor xii 
ProteomicsTowards a proteomic plasma biomarker panel for diagnosing vasculitis remission
Active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) requires intensive immunosuppressive therapy, but continued treatment after remission is achieved can cause serious harm. Reliable biomarkers to confirm remission are lacking, forcing clinicians to prolong cost-intens...
ORGANISM(S): Homo sapiens (Human) 
2026-06-05 | PXD079232 | Pride
Machine learning Vasculitis Multi-biomarker panel Plasma proteomics Anti-neutrophil cytoplasmic autoantibodies 
ProteomicsInteractome of Nematostella GW182 in HEK293 cells
Here, we dissect the function of GW182 protein in the cnidarian Nematostella, separated by 600 million years from other Metazoa. Using cultured human cells, we show that Nematostella GW182 recruits the CCR4-NOT deadenylation complexes via its tryptophan-containing motifs, thereby inhibiting translat...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD004668 | Pride
Ap-ms Lc-msms Gw182 Hek293 
ProteomicsSystemic effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the plasma and serum proteome
Cystic fibrosis (CF), resulting from a dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR), affects multiple organs through mucus obstruction and differences in secretion. The CFTR modulator drug combination elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA, ETI) has markedly i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD071549 | Pride
Serum Cystic fibrosis Elx/tez/iva Plasma Astral Dda Cftr modulator Dia Hfx Lum/iva Human Sputum Label free 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036997 | Pride
Microproteins Small peptides Human Prm 
ProteomicsPhosphoprofile reorganization of the actin binding protein Drebrin during long term depression
Drebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons. Here, we investigate the phosphorylation dynamics of DBN in the context of chemically induced long-term depression (cLTD), a synaptic p...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-17 | PXD069538 | Pride
Synaptic plasticity Drebrin Actin Long-term depression Phosphorylation Calpain 
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