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ProteomicsA lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance
Bacterial pathogens are major causes of crop diseases, leading to significant production losses. For instance, kiwifruit canker, caused by the phytopathogen Pseudomonas syringae pv. actinidiae (Psa), has posed a global challenge to kiwifruit production. Treatment with copper and antibiotics, whilst ...
ORGANISM(S): Pseudomonas phage PaMx74 
2025-08-05 | PXD035071 | Pride
Psa phage proteomics Cryo-electron microscopy Phage biocontrol Structural proteome φpsa374 
ProteomicsImmune cell proteomes of Long COVID patients have functional changes similar to those in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
To investigate the pathophysiology of Long COVID (LC), a pilot study of patients and healthy controls has used quantitative proteomics to discover changes in peripheral blood mononuclear cell (PBMC) proteoms. The proteomes of LC patients and healthy controls were analysed by Sequential Window Acquis...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD045508 | Pride
Me/cfs Swath-ms Long covid 
ProteomicssAPP a neuroprotective protein in the brain has widespread effects on the proteome of human cortical neurons related to memory mechanisms.
Human glutamatergic neurons in culture were exposed to 1 nM secreted amyloid precursor protein alpha over a time course (0, 2, 6 and 24 h) and changes in the proteome were identified with SWATH-MS.
ORGANISM(S): Homo sapiens (Human) 
2022-04-03 | PXD031704 | Pride
App Alzheimer’s disease Proteome. Sappa Human neuron 
ProteomicsThe brain protein secreted amyloid precursor protein alpha (sAPPalpha) regulates neurologically-important proteins of the cellular proteome and secretome of mouse primary astrocytes
Mouse primary astrocytes in culture were exposed to 1 nM secreted amyloid precursor protein alpha (sAPPalpha) or PBS (control) for 2 h or 6 h and changes in the cellular proteome or secretome respectively were quantified by SWATH-MS.
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD037902 | Pride
Astrocytes Amyloid precuror protein Proteome Secretome 
ProteomicsProteomic analysis of cervicovaginal fluid for endometriosis biomarker discovery
Endometriosis is a gynaecological disease facing significant diagnostic challenges, contributing to an extensive diagnostic delay. Non-invasive diagnostic biomarkers of endometriosis could expedite diagnosis and minimise the reliance on surgery to confirm endometriosis. This pilot study aimed to ide...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD065951 | Pride
Cervicovaginal fluid Endometriosis Swath-ms 
ProteomicsZNRF3 and RNF43 are active monomeric E3 ligases that self-associate
Crosslinking mass spectrometry was used to identify the site of dimerization in the RING domain of ZNRF3. The two proteins, ZNRF3 and RNF43 have a key role in regulating the number of Frizzled (FZD) receptor on cells and their inactivation causes cancer. This is because they are RING E3 ligases that...
ORGANISM(S): Homo sapiens (Human) 
2026-07-30 | PXD070424 | Pride
Znrf3 e3 ligase Cross-linking Ring dimerization 
ProteomicsThe MNV-1 ProPol precursor Cleaves a Novel Site in the NS1-2 Protein
Human noroviruses (HuNV) are members of the Caliciviridae family and are a significant cause of gastroenteritis worldwide. Cell culture models are challenging for studying the intracellular replication of HuNV, with murine norovirus (MNV) routinely used to study norovirus replication. Norovirus geno...
ORGANISM(S): Murine norovirus 1 
2026-06-08 | PXD074184 | Pride
Norovirus Tails Non-structural polyprotein Protease cleavage 
ProteomicsProteomic characterisation of extracellular vesicles derived from first trimester placentae
This study investigated the proteomes of macro-, micro- and nanovesicles derived from the same first trimester human placenta to better understand the role that these extracellular vesicles (EVs) play in maternal adaptation during healthy pregnancy. During human pregnancy, the mother undergoes majo...
ORGANISM(S): Homo sapiens (Human) 
2016-04-29 | PXD003003 | Pride
Syncytiotrophoblast Pregnancy Microvesicles Macrovesicles Nanovesicles 
ProteomicsEnamel peptide analysis to determine chromosomal sex of human remains (kōiwi tangata) of Māori-era individuals from New Zealand (Aotearoa)
Amelogenin, a protein involved in the formation of enamel occurs as two isoforms, AMEL X and AMEL Y, which are encoded on the X and Y chromosome respectively. Isoform-specific peptides can be used for the determination of the chromosomal sex in ancient teeth. This strategy was used here to determine...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD065222 | Pride
Chromosomal sex determination of human remains Amilogenin 
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