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UnknownSALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Not available
S-EPMC6717895 | biostudies-literature
ProteomicsGRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses
Enhanced synaptic wiring onto sparsely distributed memory engram cells supports contextual memory storage and recall, with negative-valence memories exhibiting greater salience. Protein-level adaptations of input-specific synaptic connectivity onto hippocampal CA1 engram cells, however, remains larg...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-24 | PXD054892 | Pride
UnknownBeneficial effects of a plant-fish oil, slow carbohydrate diet on cardio-metabolic health exceed the correcting effects of metformin-pioglitazone in diabetic pigs fed a fast-food diet.
Not available
S-EPMC8528510 | biostudies-literature
UnknownCharge Localization in Acene Crystals from Ab Initio Electronic Structure.
Not available
S-EPMC10084468 | biostudies-literature
ProteomicsComparative analyses of data independent acquisition mass spectrometric approaches: DIA, WiSIM-DIA and directDIA
With a multitude of DIA approaches developed recently, many of their features are not yet well explored. In this study we make use of a biologically relevant sample, the synaptosome, as a model to compare the spectral libraries generated by (1) DDA solely on Orbitrap (OT), (2) Orbitrap for MS1 scan...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-20 | PXD006934 | Pride
Wisim-dia Lc-ms/ms Dia Wisim Dda Directdia 
UnknownData in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis.
Not available
S-EPMC4625040 | biostudies-literature
ProteomicsThe proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
By combining immunohistochemistry (IHC) and laser microdissection (LMD) we isolated neurons with GVD and those bearing tangles separately from human post-mortem AD hippocampus (n=12) using their typical markers casein kinase (CK)1δ and phosphorylated tau (AT8). Control neurons were isolated from cog...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023199 | Pride
Alzheimer´s disease Neurofibrillary tangles Granulovacuolar degeneration Tau Neuropathology Proteomics 
ProteomicsComparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins
Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynam...
ORGANISM(S): marmosets Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-22 | PXD009251 | Pride
Synapse Species Proteomics Rat Marmoset Human Synaptosome Mouse Swath 
UnknownDifferences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins.
Not available
S-EPMC6127219 | biostudies-literature
ProteomicsMultimodal Proteomics reveals dysregulated secretion and ECM remodeling in schizophrenia patient iPSC-derived astrocytes
Astrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear. Here, we use mass spectrometry–based proteomics to profile lysates (proteome) and secreted (secretome) proteins...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD075039 | Pride
Astrocytes Proteomics Ipsc Schizophrenia Protein secretion 
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