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ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079624 | MassIVE
ProteomicsWithaferin A inhibits LFA-1-stimulated ZAP70 activity and T-cell motility
a steroidal lactone withaferin A (WFA) can inhibit T-cell motility, which is crucial for adaptive immune responses as well as autoimmune reactions. Tandem mass spectrometry identified WFA-interactome in human T-cells that were stimulated to migrate via cross-linking of the lymphocyte function-associ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026508 | Pride
T-lymphocytes Inflammation Migration Withaferin a Kinome 
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
ProteomicsAfter virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is know...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-30 | PXD039614 | Pride
T cell Mouse Reovirus 
ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo sapiens (Human) 
2015-11-12 | PXD000376 | Pride
Naive cd4+ t cells Memory cd4+ t cells Lc-msms 
ProteomicsIdentification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells
Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells. The voltage-activated Kv1.3 channel is an important regulator of T cell-mediated autoimmunity and microglia-mediated neuroinflammation. Kv1.3 channels, via pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD059644 | Pride
Autoimmune disease T-cells Potassium channel Kv1.3 
ProteomicsT-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles
The present dataset contains proteomics data from extracellular vesicles steadily released by donor matched, cultured human CD4+ and CD8+ T cells and from extracellular vesicles released within the immunological synapse.
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033917 | Pride
T-cells Immunological synapse Extracellular vesicles 
ProteomicsPostprandial effects on T cell immunity
We are working to better understand the effects of nutrient availability on T cell fate and immunity
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD057581 | Pride
Metabolism T cell 
ProteomicsSuperior Anti-tumor Efficacy of CD4+ CAR-T Cells against Acute Leukemias
While chimeric antigen receptor T-cell (CART) therapy has shown impressive therapeutic efficacy in several hematologic malignancies, primary or secondary treatment failure remains a significant challenge driving investigators to explore opportunities to improve the functionality of CART products. In...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD060508 | Pride
Acute leukemia Antitumor activity Car-t therapy Cd4+ t-cells 
ProteomicsCul5 regulates CD4+ T cell fate choice and allergic inflammation
Antigen encounter directs CD4+ T cells to differentiate into T-helper or -regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern -helper versus -regulatory fate remain poorly understood. Here, we show that the E3 ubiquitin...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD028492 | Pride
Cis T-cell Asthma Allergy Cul5 Crl5 Cd4 Ubiquitin 
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