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ProteomicsLabel-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors
Purpose: To identify proteins and (molecular/biological) pathways associated with differences between benign and malignant epithelial ovarian tumors. Experimental procedures: Serum of six patients with a serous adenocarcinoma of the ovary was collected before treatment, with a control group consisti...
ORGANISM(S): Homo sapiens (Human) 
2014-10-13 | PXD001084 | Pride
Ovarian cancer Topx peptide quantitation Serum Tissue All ions fragmentation Label free quantitation 
ProteomicsGlobal mapping of rat plasma proteins with a native proteomic approach using nondenaturing micro 2DE and label-free quantitative LC-MS/MS
Plasma samples from adult male rats were separated by nondenaturing micro 2DE and a representative gel was selected, on which a total of 136 CBB-stained spots were numbered and subjected to in-gel digestion and label-free quantitative LC-MSE (MS/MS in data-independent acquisition mode). The analysi...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-10-14 | PXD004395 | Pride
Native proteomics Adult male rat plasma proteome Nondenaturing micro 2de Global mapping Label-free quantitative lc-mse 
ProteomicsLabel-free proteome analysis of plasma from patients with breast cancer: stage-specific protein expression
The breast cancer presents one of the most commonly diagnosed types of cancer among women and its mortality rates remain very high probably due to the diagnosis of this disease is hampered by the lack of an accurate detection method. Since that change of protein expression as well modifications in i...
ORGANISM(S): Homo sapiens (Human) 
2017-02-20 | PXD003106 | Pride
Human Breast cancer Lc-mse Plasma 
ProteomicsLabel free IMS-MSE protein quantification for plant Golgi protein localisation and abundance
Golgi resident proteins in Arabidopsis thaliana are challenging to quantify since the abundance of this organelle is relatively low within the cell. In this study an organelle fractionation approach, targeting the Golgi apparatus, was combined with a label free quantitative MS, data-independent acqu...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-07-07 | PXD001056 | Pride
Arabidopsis thaliana Mse Hdmse Lopims Lopit Organelle proteomics Ims-mse Data-independent acquisition Absolute quantitation 
ProteomicsLabel-free quantitative Proteomics Analysis Reveals Distinct Molecular characteristics in Endocardial Endothelium
Endocardial endothelium, which lines the chambers of the heart, is distinct in its origin, structure, and function. However, though functionally very important, no studies at protein level have been conducted so far characterizing endocardial endothelium. In this study, we used endothelial cells fro...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-06-29 | PXD009194 | Pride
Aorta Label free proteomics Endocardium Endothelium 
ProteomicsHybrid label-free quantification proteomics and QconCAT-assisted quantification of amylase-trypsin inhibitors from flours of 150 wheat varieties (3 field locations) by LC-MSE
Wheat (Triticum aestivum ssp. aestivum) contributes to 20% of the human protein supply, delivers essential amino acids and is of fundamental importance for bread and pasta quality. Wheat proteins are also involved in adverse human reactions like celiac disease, wheat allergy and the non-celiac wheat...
ORGANISM(S): Triticum aestivum (Wheat) 
2021-09-10 | PXD023654 | Pride
Mse Breeding Amylase-trypsin inhibitors (atis) Synapt g2-s Proteomics Wheat varieties Qconcat Label-free quantification (lfq) Non-celiac wheat sensitivity (ncws) Data-independent acquisition (dia) 
ProteomicsBenchmarking label-free quantification based on data-independent acquisition (DIA) workflows
Label-free quantification based on data-independent acquisition (DIA) workflows is increasingly popular. Several software tools have been recently published or are commercially available. The present study focuses on the critical evaluation of three different software packages (Progenesis, synapter ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2017-04-06 | PXD001240 | Pride
Human Yeast E.coli 
ProteomicsProteomics profiling to distinguish DOCK8 deficiency from atopic dermatitis
Background: DOCK8 deficiency is an autosomal recessive form of hyperimmunoglobulinemia E syndrome (HIES). Severe atopic dermatitis (AD) shares with DOCK8 deficiency some clinical symptoms, including eczema, eosinophilia, and increased serum IgE levels. The deficiency of DOCK8 protein is potentially ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-17 | PXD029052 | Pride
Atopic dermatitis Multiple-reaction monitoring Label-free proteomics Lc-mse synaptg2 Dedicator of cytokinesis (dock8) Hyper ige syndrome (hies) 
ProteomicsHybrid QconCAT-based Targeted Absolute and Data-independent Acquisition-based Label-free Quantification Enables In-depth Proteomic Characterization of Wheat ATI Extracts
In this study, we present a novel hybrid data-independent acquisition LC-MS approach, combining QconCAT technology with short microflow LC gradients and DIA and apply the method towards the quantitative proteome analysis of ATI extracts from wheat flour. The novel method is fast, robust and reproduc...
ORGANISM(S): Triticum aestivum (Wheat) 
2021-04-22 | PXD021381 | Pride
Wheat Dia Data-independent acquisition Qconcat Absolute quantification Microflow lc-ms Ati Triticum Amylase-trypsin inhibitor 
MetabolomicsGlobal transcription and metabolic profiles of five tissues in pepper fruits

The sample to be tested was fully ground into powder in the grinder, 50 mg of the sample was freeze-dried, 1000 μL of the extraction solution containing the inner target was added (methanol:acetonitrile:water, 2:2:1, v/v/v, internal standard concentration 20 mg/L) and vortex mixed for 30 s; then ...

2024-07-12 | MTBLS10002 | MetaboLights
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