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TranscriptomicsDivergence of Transcription Factor Binding Sites in Related Yeast Species
A fundamental problem in biology is the molecular basis for divergence among related organisms. We have investigated the level of divergence of transcription factor binding sites for two key factors that regulate developmental processes in the budding yeasts. The genomic binding locations for the St...
ORGANISM(S): Saccharomyces mikatae 
2007-09-06 | E-GEOD-5421 | biostudies-arrayexpress
ProteomicsKinetics of abacavir-induced remodelling of the Major Histocompatibility Complex class I peptide repertoire
Characterisation of the kinetics of abacavir-induced perturbation of the immunopeptidome of the Major Histocompatibility Complex (MHC) class I molecule HLA-B*57:01.
ORGANISM(S): Homo sapiens (Human) 
2021-05-11 | PXD024331 | Pride
Mhc i antigen presentation Drug hypersensitivity Peptide selection Abacavir T cells Human leukocyte antigen (hla) Immunopeptidome Tapasin 
TranscriptomicsDrug-inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites
Plasmodium and Toxoplasma are parasites of major medical importance that belong to the Apicomplexa phylum of protozoa. These parasites transform into various stages during their life cycle and express a specific set of proteins at each stage. Although still little is known of how gene expression is ...
ORGANISM(S): Toxoplasma gondii 
2010-06-21 | E-GEOD-15241 | biostudies-arrayexpress
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsMSP-MS of Cathepsin L and Cathepsin V pH 5.5
MSP-MS of Cathepsin L and Cathepsin V pH 5.5 at 37C
ORGANISM(S): Synthetic Construct (ncbitaxon:32630) 
MSV000088091 | MassIVE
ProteomicsAssessing Target Specificity of the Small Molecule Inhibitor Marimastat to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling
New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of medically significant venom toxins in vivo and in vitro. The developmen...
ORGANISM(S): Crotalus atrox 
2024-06-22 | PXD046399 | Pride
Thermal proteome profiling Snake venom Metalloprotease 
TranscriptomicsTranscription profiling of human coronary artery endothelial cells treated with ADMA at 2uM (a pathophysiological dose) and 100uM (a pharmacological dose), for 24h
Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis. Plasma ADMA has been implicated as a major novel cardiovascular risk factor, but the mechan...
ORGANISM(S): Homo sapiens 
2005-09-01 | E-MEXP-377 | biostudies-arrayexpress
ProteomicsSerum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | MassIVE
ProteomicsThe major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus
Background: The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention and treatment. This study aimed to determine ho...
ORGANISM(S): Homo sapiens (Human) 
2023-09-21 | PXD043880 | Pride
Lipidomic Sphingolipid Hippocampus Myelin Tmem106b Proteomic Ageing Neurodegeneration 
TranscriptomicsTranscription profiling of mouse Atm-/-,mTerc-/-,p53-/- triple knock-out lymphoma vs normal
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7607 | biostudies-arrayexpress
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