Sort   by:  
 Page size 
ProteomicsFOXP1 is a transcriptional Coactivator of Wnt/β-catenin signaling in Diffuse Large B-cell Lymphoma
We used a mass spectrometry-coupled lentiviral ‘CD-tagging’ mutagenesis approach to identify genes that activate Wnt/β-catenin signaling. Human A375 melanoma cells containing a β-catenin-driven GFP (green fluorescent protein) transcriptional reporter were transduced with CDBF lentivirus. When integr...
ORGANISM(S): Homo sapiens (Human) 
2016-07-05 | PXD001485 | Pride
Flag apms Gain-of-function screening Wnt signaling Foxp1 
ProteomicsCompetitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits Glycogen Synthase Kinase 3 Beta and Activates WNT Signaling
The cellular and organismal phenotypic response to a small molecule kinase inhibitor is defined collectively by the inhibitor’s targets and their functions. The selectively of small molecule kinase inhibitors is commonly determined in vitro, using purified kinases and substrates. Recently, competiti...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-12-07 | PXD006139 | Pride
Polypharmacology Gsk3β Wnt signaling Kinase Chemoproteomics 
ProteomicsTargeted proteomics quantittation of NRF2 signaling and predictive biomarkers in HNSCC
The NFE2L2/NRF2 oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a m...
ORGANISM(S): Homo sapiens (Human) 
2023-06-13 | PXD042949 | Pride
Lc-ms/ms 
ProteomicsMolecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
NFE2L2/NRF2 is a transcription factor and master regulator of the cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, resulting in increased cellular fitness, chemo-radiation resistance, metabolic reprogramming and immune evasion. NRF2 protein le...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD015884 | Pride
Sad-b Sad-a Brsk2 Ampk Nrf2 Mtor signaling Brsk1 Phosphoproteomics Antioxidant response 
ProteomicsMAFG proximity proteomic analysis in melanoma cells
Proximity proteins of melanoma cell line WM164 expressing TurboID-NLS or TurboID-MAFG was analyzed.
ORGANISM(S): Homo sapiens (Human) 
2026-02-19 | PXD055213 | Pride
Turboid Mafg Proximity Melanoma 
ProteomicsSubstrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase
We inhibited the proteosome to ‘trap’ ubiquitylated substrates on the SCFFBXW11 E3 complex. Comparative mass spectrometry analysis of immunopurified FBXW11 protein complexes before and after proteosome inhibition revealed known and putatively novel substrates.
ORGANISM(S): Homo sapiens (Human) 
2014-10-24 | PXD001062 | Pride
Btrc Fbxw11 E3 ubiquitin ligase 
ProteomicsTargeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
The NFE2L2/NRF2 oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a m...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD041162 | Pride
Hnscc Nrf2 Luad Lusc 
ProteomicsTargeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
The NFE2L2/NRF2 oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a m...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD041163 | Pride
Hpv Oropharynx tumor Oral cavity tumor Hnscc Nrf2 
TranscriptomicsMultifaceted maturation of monocyte-derived dendritic cells stimulated by intracellular bacteria
Background: It has been shown that intracellular pathogens hijack DC functions to evade immune defense mechanisms. In this study, we investigated the responses of human monocyte derived DCs to four intracellular bacteria, Tropheryma whipplei, Coxiella burnetii, Brucella abortus and Orientia tsutsuga...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-49016 | biostudies-arrayexpress
UnknownEnhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth.
Not available
S-EPMC5970167 | biostudies-literature
Sort   by:  
 Page size