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ProteomicsEffect of FAK K454R mutation or knockout on composition of extracellular matrix and associated membrane proteins in 3D culture of ID8 mouse ovarian surface epithelial cells
ID8 mouse ovarian surface epithelial cells with or without K454R mutant and knockout of FAK were cultured as spheroid cultures. The cells were hypotonically lysed and washed out, and the insoluble material was analyzed by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2019-08-30 | PXD013062 | Pride
Fak Id8 Epithelial Mouse 3d culture Ovarian 
ProteomicsSIK2 phosphorylation in response to glucagon or insulin in murine hepatocytes
The phosphorylation state of human HA-tagged-SIK2, adenovirally introduced in murine hepatocytes (C57/BL/6 strain) was analysed in unstimulated and in response to glucagon- or insulin- treated conditions. Background:- LKB1 is a master kinase that regulates metabolism and growth through AMPK and 12 o...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-08-08 | PXD001032 | Pride
Hepatic glucose production Hepatocytes Camp Crtc2 Ampk Glucagon Ampk-related kinase Lkb1 Sik2 Insulin Creb 
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
UnknownGene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes.
Not available
S-EPMC8415425 | biostudies-literature
UnknownIdentification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Not available
S-EPMC6602064 | biostudies-literature
UnknownIntegrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.
Not available
S-EPMC9470534 | biostudies-literature
UnknownBreast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk.
Not available
S-EPMC7675034 | biostudies-literature
UnknownIdentification of common variants associated with human hippocampal and intracranial volumes.
Not available
S-EPMC3635491 | biostudies-literature
UnknownFine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Not available
S-EPMC6974400 | biostudies-literature
UnknownIdentification of six new susceptibility loci for invasive epithelial ovarian cancer.
Not available
S-EPMC4445140 | biostudies-literature
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