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ProteomicsMouse connective tissue mast cell proteome
Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products con...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-12 | PXD015040 | Pride
Mouse Peritoneal mast cell Mast cell 
ProteomicsHuman connective tissue mast cell proteome
Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products con...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD014978 | Pride
Human Fat mast cell Skin mast cell 
ProteomicsCell-intrinsic steroidogenesis regulates mast cell function
Steroid hormones are well known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme Cyp11a1 and produce pregnenolone. Cy...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-04 | PXD079140 | Pride
Mast cell degranulation Cyp11a1 Mast cell Steroid-signalling   anaphylaxis Steroidogenesis Pregnenolone 
ProteomicsCell-intrinsic steroidogenesis regulates mast cell function
Steroid hormones are well known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme Cyp11a1 and produce pregnenolone. Cy...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-04 | PXD079414 | Pride
Mast cell degranulation Cyp11a1 Mast cell Steroid-signalling   anaphylaxis Steroidogenesis Pregnenolone 
ProteomicsBone marrow-derived mast cells +- IL-33 48h
Mast cells are tissue resident granulocytes which are most abundant at the interface between tissues and the external environment, such as around blood vessels, in the skin or mucosal surfaces in the lungs and gut. Pathologically they are involved in allergic reactions and anaphylaxis, however they ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD033759 | Pride
Granulocyte Mouse Lc-ms Mast cell Il-33 
ProteomicsA Nerve and Mast Cell Sentinel System Releases Extracellular Condensates to Induce Macrophage Repair
The peritoneal cavity has a higher density of immune cells then does blood. These cells are primarily localized within the bulk flow of fluid. As such, any perturbation within the peritoneum, ranging from a sterile injury to endometriosis to ovarian cancer, requires that the immune cells find a way ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-17 | PXD061150 | Pride
Granules Mouse Mast cell 
ProteomicsMast cells modulate macrophage through release of Csf1
To systematically identify mast cells-released mediators, we analysed the proteome and secretome of antigen-activated primary mouse mast cells using quantitative mass spectrometry-based proteomics and identified Csf1 as a novel preformed mast cell mediator.
ORGANISM(S): Mus musculus (Mouse) 
2025-06-23 | PXD050282 | Pride
Mast cell proteome Macrophage differentiation Macrophage polarisation Secretome 
ProteomicsGlobal phosphoproteomics elicited by the SCF/KIT axis in human skin mast cells unveil capicua as a potent KIT repressor
Global phosphoproteomics can reveal signaling cascades in unprecedented detail. The SCF/KIT axis represents a vital hematopoietic receptor tyrosine kinase (RTK) system with gain-of-function mutations prompting the development of mastocytosis and leukemia. Here, we employed a label-free phosphoproteo...
ORGANISM(S): Homo sapiens (Human) 
2022-11-15 | PXD028252 | Pride
Phosphoproteome Human Scf Mast cells 
TranscriptomicsTranscriptome and proteome analysis of tyrosine kinase treated canine mast cell tumour cells identifies potentially KIT signalling-dependent genes
Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied as a therapeutic agent for this tumour type. However, little is known on the downstream tar...
ORGANISM(S): Canis lupus familiaris 
2012-07-24 | E-GEOD-32657 | biostudies-arrayexpress
ProteomicsProteomic profiling of KIT-containing EVs secreted by neoplastic human mast cells (SUB2)
Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells. Despite potential contributions to diseases, KIT-co...
ORGANISM(S): Homo sapiens (Human) 
2025-12-02 | PXD033890 | Pride
Exosomes Microvesicles Extracellular vesicles Kit Immunocapture Mast cell 
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