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ProteomicsHuman acute myeloid leukemia (AML) cell line LFQ, comparison between doxycycline-inducible control shRNA and Pim2 shRNA
Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20-30% of AML cases. This subtype usually responds poorly to conventional therapies including FLT3 tyrosine kinase inhibitors (TKIs) due to molecular bypass mechanisms. New therapeutic strategies are t...
ORGANISM(S): Homo sapiens (Human) 
2017-09-18 | PXD005880 | Pride
Aml Rna interference Pim2 Lfq 
ProteomicsComparison of LFQ and TMT-based quantitative proteomics towards toxicology research
Here, we aimed to compare two of the most commonly used global proteomics strategies, label-free quantification (LFQ) and tandem mass tag-based quantification (TMT) to identify the most suitable tool for toxicology research questions on the systemic level. Using a biological case study of HepG2 expo...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020248 | Pride
Toxicoproteomics Benzo[a]pyrene Tandem mass tag (tmt) Label free-quantification (lfq) Hepg2 
ProteomicsMass Dynamics 1.0: A streamlined, web-based environment for analyzing, sharing and integrating Label-Free Data
Label Free Quantification (LFQ) of shotgun proteomics data is a popular and robust method for the characterization of relative protein abundance between samples. Many analytical pipelines exist for the automation of this analysis and some tools exist for the subsequent representation and inspection ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2022-04-13 | PXD028038 | Pride
Maxquant Benchmarking Label-free quantification Web-based software tool Automated data analysis 
ProteomicsLFQ Burkholderia Cenocepacia mutant comparsion
Comparsion of multiple BC k56-2 muants to assess protoeme chnages. seven strain comparsion between WT vs delta pglL vs delta 1086 vs delta 2974 vs delta CepI vs delta CepR vs delta pglL complemented AmrAB::S7-pglL-his. LFQ based quantification
ORGANISM(S): Burkholderia cenocepacia K56-2Valvano 
2019-11-01 | PXD014581 | Pride
Glycosylation mutant Lfq Burkholderia Quorum sensing 
ProteomicsLFQ of Campylobacter fetus subsp. fetus strains
Comparsion of proteomes of Campylobacter fetus subsp. fetus to compare protein level via iBAQ analysis, expression (by LFQ) and coverage between Campylobacter fetus subsp. fetus strain82-40 vs Campylobacter fetus subsp. fetus strain ATCC 27374
ORGANISM(S): Campylobacter fetus subsp. fetus 82-40 
2020-05-25 | PXD014538 | Pride
Campylobacter fetus subsp. fetus Lfq Proteome 
ProteomicsProteome-wide evaluation of two common protein quantification methods
Proteomics experiments commonly aim to estimate and detect differential abundance across all expressed proteins. Within this experimental design, some of the most challenging measurements are small fold changes for lower abundance proteins. While bottom-up proteomics methods are approaching comprehe...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2018-04-05 | PXD007683 | Pride
Tmt Lfq Maxquant 
ProteomicsLFQ of compund treated Haemonchus contortus
This study applied the LFQ proteome to infer molecular targets and protein–ligand interactions of candidate nematocidal compounds in Haemonchus contortus. Protein extracts were prepared under standardised conditions, and then processed for quantitative proteomics using high-resolution LC-MS/MS. Resu...
ORGANISM(S): Haemonchus contortus (Barber pole worm) 
2026-07-19 | PXD075211 | Pride
ProteomicsEffects of contact allergens on THP-1 cells – LFQ- and SILAC-based untargeted proteomics
In this study, the effects of the contact allergens BQ, DNCB, NBB, Ni, and PPD were investigated in THP-1 cells. For this purpose, LFQ- and SILAC-based untargeted proteomics were applied.
ORGANISM(S): Homo sapiens (Human) 
2023-09-13 | PXD031017 | Pride
Silac Lfq Thp-1 Contact allergens 
ProteomicsComparative Evaluation of MaxQuant and Proteome Discoverer MS1-based Protein Quantification Tools
MS1-based label-free quantification can compare precursor ion peaks across runs, allowing reproducible protein measurements. Among bioinformatic platforms enabling MS1-based quantification, MaxQuant (MQ) is one of the most used, while Proteome Discoverer (PD) has recently introduced the Minora tool....
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-31 | PXD022169 | Pride
Dynamic range Proteomics Mass spectrometry Specificity Sensitivity Accuracy Precision Label-free quantification Differential analysis 
ProteomicsColorectal cancer anti-ORF1p LFQ IP-MS
Here, three colorectal tumors were subjected to anti-ORF1p LFQ, IP-MS: (A) Krukenberg Carcinoma, Ovary; (B) Metastatic Rectal Adenocarcinoma, Liver; (C) Adenocarcinoma, Colon. These were accompanied by matched normal IP controls and/or mouse IgG IP controls. The objective is to map LINE-1 RNP intera...
ORGANISM(S): Homo sapiens (Human) 
2019-08-23 | PXD013743 | Pride
Lc-msms Patient tumor Line-1 L1 Retrotransposon Crc 
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