Sort   by:  
 Page size 
ProteomicsC9ORF72 interaction with cofilin modulates actin dynamics in motoneurons
Intronic hexanucleotide expansions in C9ORF72 are common in ALS and FTLD, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non ATG-initiated translation are responsible for the pathophysiology. We determined the interactome of C9ORF72 in motoneurons and fou...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-30 | PXD004913 | Pride
Ftld Cofilin Als C9orf72 
ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-15 | PXD018659 | Pride
Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Lc-msms Pdac Pancreatic cancer Extracellular matrix 
ProteomicsA mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori
We established a generic pipeline for the identification of surface-exposed vaccine candidates in gram-negative bacteria. Using Helicobacter pylori as a model organism, our approach combines design of experiment driven surface shaving with quantitative mass spectrometry to identify 22 highly conserv...
ORGANISM(S): Helicobacter pylori J99 (Campylobacter pylori J99) 
2019-11-11 | PXD012566 | Pride
Proteomics Vaccine Surfome Helicobacter pylori 
ProteomicsTDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
Whole proteome quantification identified upregulation of the ESCRT component VPS4B upon TDP-43 knockdown in neurons.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-09-29 | PXD004756 | Pride
Ftld Recycling endosomes Tdp-43 Als Erbb4 
ProteomicsQuantitative proteomics of Uukuniemi virus - host cell interactions reveals GBF1 as proviral host factor for phleboviruses
Novel tick-borne phleboviruses in the Phenuiviridae family, which are highly pathogenic in humans and all closely related to Uukuniemi virus (UUKV), have recently emerged on different continents. How phleboviruses assemble, bud, and exit cells remains largely elusive. Here, we performed high-resolut...
ORGANISM(S): Homo sapiens (Human) 
2019-10-02 | PXD015194 | Pride
Gbf1 Viral glycoprotein interactions Flavivirus Phenuiviridae Quantitative proteomics Retrovirus Viral assembly Phlebovirus Alphavirus Viral replication Hepacivirus Rhabdovirus Viral egress Adenovirus Coronavirus Uukuniemi 
ProteomicsPD-1-targeted immunotherapy in NASH-triggered liver cancer induces pro-tumorigenic environment through CD8+PD-1+ T-cells
Immunotherapy has opened hitherto unknown possibilities to treat cancer. Whereas some cancer types (e.g. melanoma) can be efficiently treated, others lack measurable positive effects (e.g. PDAC). Moreover, stratification of responders/non-responders is only possible in some cancer types (e.g. melano...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-03 | PXD017236 | Pride
Immunotherapy Cd8+pd1+ Nash 
ProteomicsMononuclear phagocyte phenotypes in a multiple sclerosis model
Mononuclear phagocytes are key regulators of both tissue damage and repair in neuroinflammatory conditions such as multiple sclerosis (MS). To examine divergent phagocyte phenotypes in the inflamed central nervous system (CNS) we introduce an in vivo imaging approach combined with RNAseq and proteom...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-10 | PXD010245 | Pride
Mononuclear pahgocytes Macrophage Central nervous system Experimental autoimmune encephalomyelitis Multiple sclerosis Microglia 
ProteomicsSecretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function
The[Q3] gelatinases, matrix metalloproteinase 2 (MMP-2) and MMP-9, are key for leukocyte penetration of the brain parenchymal border in neuroinflammation and the functional integrity of this barrier; however, it is unclear which MMP substrates are involved. Using a tailored, sensitive, label-free ma...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD043521 | Pride
Gelatinase Secretomics Mass spec 
ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azid...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-07-20 | PXD040084 | Pride
Submitter keyword: lc-msms Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Pdac Pancreatic cancer Extracellular matrix 
ProteomicsDeep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics
The fatal neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the most common motoneuron disease and genetic cause of infant death, respectively. Various in vitro model systems have been established to investigate motoneuron disease mechanisms - in p...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-08 | MSV000084939 | MassIVE
Sort   by:  
 Page size