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ProteomicsC9ORF72 interaction with cofilin modulates actin dynamics in motoneurons
Intronic hexanucleotide expansions in C9ORF72 are common in ALS and FTLD, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non ATG-initiated translation are responsible for the pathophysiology. We determined the interactome of C9ORF72 in motoneurons and fou...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-30 | PXD004913 | Pride
Ftld Cofilin Als C9orf72 
ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-15 | PXD018659 | Pride
Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Lc-msms Pdac Pancreatic cancer Extracellular matrix 
ProteomicsIdentification of Covalent Modifications Regulating Immune Signaling Complex Composition and Phenotype
Cells signal through rearrangements of protein communities governed by covalent modifications and reversible interactions of distinct sets of proteins. A method that identifies those post-transcriptional modifications regulating signaling complex composition and functional phenotypes in one experime...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD010996 | Pride
Human Ap-ms Tlr2 Methylation Monocytes Acetylation Phosphorylation 
ProteomicsA mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori
We established a generic pipeline for the identification of surface-exposed vaccine candidates in gram-negative bacteria. Using Helicobacter pylori as a model organism, our approach combines design of experiment driven surface shaving with quantitative mass spectrometry to identify 22 highly conserv...
ORGANISM(S): Helicobacter pylori J99 (Campylobacter pylori J99) 
2019-11-11 | PXD012566 | Pride
Proteomics Vaccine Surfome Helicobacter pylori 
ProteomicsCholesterol sensing by CD81 is important for hepatitis C virus entry
CD81 is a protein found in the cells of all vertebrates, including humans. CD81 performs an important role in the natural biology of a cell: it organises collections of proteins at the cell surface, allowing them to function together. Through this role, CD81 facilitates the activation of immune cell...
ORGANISM(S): Homo sapiens (Human) 
2020-12-02 | PXD019260 | Pride
Proteomics Immune cell Hepatitis c Signal transduction Cd81 Mass spectrometry 
ProteomicsTDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
Whole proteome quantification identified upregulation of the ESCRT component VPS4B upon TDP-43 knockdown in neurons.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-09-29 | PXD004756 | Pride
Ftld Recycling endosomes Tdp-43 Als Erbb4 
ProteomicsQuantitative proteomics of Uukuniemi virus - host cell interactions reveals GBF1 as proviral host factor for phleboviruses
Novel tick-borne phleboviruses in the Phenuiviridae family, which are highly pathogenic in humans and all closely related to Uukuniemi virus (UUKV), have recently emerged on different continents. How phleboviruses assemble, bud, and exit cells remains largely elusive. Here, we performed high-resolut...
ORGANISM(S): Homo sapiens (Human) 
2019-10-02 | PXD015194 | Pride
Gbf1 Viral glycoprotein interactions Flavivirus Phenuiviridae Quantitative proteomics Retrovirus Viral assembly Phlebovirus Alphavirus Viral replication Hepacivirus Rhabdovirus Viral egress Adenovirus Coronavirus Uukuniemi 
ProteomicsLoss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to Chromatin
Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stresses. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal development by regulating axon growth. Hnrnpr pre-mRNA undergoes a...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-01 | PXD022467 | Pride
Proteomics Hnrnpr Ip Ftld Als Motoneurons Dna damage response 
ProteomicsGenomic contamination causes NLRP1 hypersensitivity and altered cell surface markerGenomic contamination causes NLRP1 hypersensitivity and altered cell surface marker expression in Nlrp3-/- macrophagesGenomic contamination causes NLRP1 hypersensitivity and altered cell surface marker expression in Nlrp3-/- macrophages
The NLRP1 and NLRP3 inflammasomes are critical immune signaling hubs that drive cytokine release and inflammatory cell death, and have been implicated in the pathogenesis of diverse diseases. Much of our understanding of inflammasome biology stems from experiments performed in transgenic mouse lines...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-16 | PXD046782 | Pride
Inflammasome Mouse genetics Immunology 
ProteomicsIntracellular bacteria engage a novel STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling
The innate immune system is crucial for eventual control of infections, but may also contribute to pathology. Listeria monocytogenes is an intracellular gram-positive bacteria and a major cause of food-borne disease. However, important knowledge on the interactions between L. monocytogenes and the i...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-20 | PXD012135 | Pride
Phosphoproteomics Sting Cgas Intracellular bacteria Nucleic acid sensing 
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